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1000 Titel
  • Phthalates and Perfluorooctanesulfonic Acid in Human Amniotic Fluid: Temporal Trends and Timing of Amniocentesis in Pregnancy
1000 Autor/in
  1. Jensen, Morten Søndergaard |
  2. Nørgaard-Pedersen, Bent |
  3. Toft, Gunnar |
  4. Hougaard, David M. |
  5. Bonde, Jens Peter |
  6. Cohen, Arieh |
  7. Thulstrup, Ane Marie |
  8. Ivell, Richard |
  9. Anand-Ivell, Ravinder |
  10. Lindh, Christian H. |
  11. Jönsson, Bo A.G. |
1000 Erscheinungsjahr 2012
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-03-07
1000 Erschienen in
1000 Quellenangabe
  • 120(6): 897-903
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2012
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1289/ehp.1104522 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385442/ |
1000 Ergänzendes Material
  • https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.1104522#d3e1714 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability. OBJECTIVES: We aimed to detect various phthalate metabolites and perfluorooctanesulfonic acid (PFOS) in human amniotic fluid, to study temporal exposure trends, and to estimate potential associations with gestational week of amniocentesis and maternal age and parity at amniocentesis. METHODS: We studied 300 randomly selected second-trimester amniotic fluid samples from a Danish pregnancy-screening biobank covering 1980 through 1996. We used only samples from male offspring pregnancies. We assayed the environmental pollutants by liquid chromatography/triple quadrupole mass spectrometry and analyzed data using generalized linear regression models. RESULTS: We detected the di(2-ethylhexyl) phthalate (DEHP) metabolite mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP) at a median concentration of 0.27 ng/mL [interquartile range (IQR): 0.20–0.37 ng/mL], the diisononyl phthalate (DiNP) metabolite mono(4-methyl-7-carboxyheptyl) phthalate (7cx-MMeHP) at 0.07 ng/mL (IQR: 0.05–0.11 ng/mL), and PFOS at 1.1 ng/mL (IQR: 0.66–1.60 ng/mL). An increase of 1 calendar year was associated with 3.5% lower [95% confidence interval (CI): –4.8%, –2.1%] 5cx-MEPP levels and with 7.1% higher (95% CI: 5.3%, 9.0%) 7cx-MMeHP levels. For each later gestational week of amniocentesis, 5cx-MEPP was 9.9% higher (95% CI: 4.8%, 15.2%), 7cx-MMeHP was 8.6% higher (95: CI: 2.7%, 14.9%), and PFOS was 9.4% higher (95: CI: 3.3%, 15.9%). We observed no associations with maternal age or parity. CONCLUSIONS: Measured metabolite levels appeared to parallel decreasing DEHP exposure and increasing DiNP exposure during the study period. The environmental pollutant levels were positively associated with later gestational age at amniocentesis during pregnancy weeks 12–22.
1000 Sacherschließung
lokal amniocentesis
lokal biomonitoring
lokal temporal trend
lokal pregnancy
lokal phthalates
lokal biobank
lokal perfluorinated compounds
lokal amniotic fluid
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SmVuc2VuLCBNb3J0ZW4gU8O4bmRlcmdhYXJk|https://frl.publisso.de/adhoc/creator/TsO4cmdhYXJkLVBlZGVyc2VuLCBCZW50|https://frl.publisso.de/adhoc/creator/VG9mdCwgR3VubmFy|https://frl.publisso.de/adhoc/creator/SG91Z2FhcmQsIERhdmlkIE0u|https://frl.publisso.de/adhoc/creator/Qm9uZGUsIEplbnMgUGV0ZXI=|https://frl.publisso.de/adhoc/creator/Q29oZW4sIEFyaWVo|https://frl.publisso.de/adhoc/creator/VGh1bHN0cnVwLCBBbmUgTWFyaWU=|http://orcid.org/0000-0001-6513-2109|http://orcid.org/0000-0002-4976-4314|https://frl.publisso.de/adhoc/creator/TGluZGgsIENocmlzdGlhbiBILg==|https://frl.publisso.de/adhoc/creator/SsO2bnNzb24sIEJvIEEuRy4=
1000 Label
1000 Förderer
  1. Danish Environmental Protection Agency
  2. Danish Ministry of Interior and Health, Research Centre for Environmental Health
  3. Dagmar Marshall Foundation
  4. Aarhus University Research Foundation
  5. Foundation for Advancement of Medical Science
  6. Knud Højgaard’s Foundation
  7. Jacob Madsen and Olga Madsen’s Foundation
  8. Christian and Ottilia Brorson’s Foundation
  9. Danish Ramazzini Centre
  10. C.C. Klestrup and Henriette Klestrup’s Memorial Foundation
  11. Carl and Ellen Hertz’s Foundation
  12. Swedish Council for Working Life and Social Research
  13. Skåne County Council’s Research and Development Foundation
  14. Lund University, Medical Faculty
  15. Aarhus University, Faculty of Health Sciences
1000 Fördernummer
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1000 Förderprogramm
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  8. Scholarship for Young Scientists
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  11. Scolarship for Danish Medical Science
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  14. -
  15. Ph.D. scholarship
1000 Dateien
  1. Copyright and Permissions EHP             
1000 Objektart article
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1000 @id frl:6410742.rdf
1000 Erstellt am 2018-10-23T14:46:39.602+0200
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