LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer

  1. Cadenas, Cristina ORCID logo
  2. Vosbeck, Sonja
  3. Edlund, Karolina ORCID logo
  4. Grgas, Katharina
  5. Madjar, Katrin
  6. Hellwig, Birte
  7. Adawy, Alshaima
  8. Glotzbach, Annika
  9. Stewart, Joanna D.
  10. Lesjak, Michaela S.
  11. Franckenstein, Dennis
  12. Claus, Maren
  13. Hayen, Heiko
  14. Schriewer, Alexander
  15. Gianmoena, Kathrin
  16. Thaler, Sonja
  17. Schmidt, Marcus
  18. Micke, Patrick ORCID logo
  19. Pontén, Fredrik
  20. Mardinoglu, Adil
  21. Zhang, Cheng
  22. Käfferlein, Heiko U.
  23. Watzl, Carsten ORCID logo
  24. Frank, Saša
  25. Rahnenführer, Jörg ORCID logo
  26. Marchan, Rosemarie ORCID logo
  27. Hengstler, Jan ORCID logo

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Cadenas_et_al-2019-International_Journal_of_Cancer.pdf 5,14MB
WeightNameValue
1000 Titel
  • LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer
1000 Autor/in
  1. Cadenas, Cristina |
  2. Vosbeck, Sonja |
  3. Edlund, Karolina |
  4. Grgas, Katharina |
  5. Madjar, Katrin |
  6. Hellwig, Birte |
  7. Adawy, Alshaima |
  8. Glotzbach, Annika |
  9. Stewart, Joanna D. |
  10. Lesjak, Michaela S. |
  11. Franckenstein, Dennis |
  12. Claus, Maren |
  13. Hayen, Heiko |
  14. Schriewer, Alexander |
  15. Gianmoena, Kathrin |
  16. Thaler, Sonja |
  17. Schmidt, Marcus |
  18. Micke, Patrick |
  19. Pontén, Fredrik |
  20. Mardinoglu, Adil |
  21. Zhang, Cheng |
  22. Käfferlein, Heiko U. |
  23. Watzl, Carsten |
  24. Frank, Saša |
  25. Rahnenführer, Jörg |
  26. Marchan, Rosemarie |
  27. Hengstler, Jan |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-17
1000 Erschienen in
1000 Quellenangabe
  • 145(4):901-915
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/ijc.32138 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618071/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32138#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high‐density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that severe oxidative stress leading to AMPK activation triggers LIPG upregulation, resulting in intracellular lipid droplet accumulation in breast cancer cells, which supports survival. Neutralizing oxidative stress abrogated LIPG upregulation and the concomitant lipid storage. In human breast cancer, high LIPG expression was observed in a limited subset of tumours and was significantly associated with shorter metastasis‐free survival in node‐negative, untreated patients. Moreover, expression of PLIN2 and TXNRD1 in these tumours indicated a link to lipid storage and oxidative stress. Altogether, our findings reveal a previously unrecognized role for LIPG in enabling oxidative stress‐induced lipid droplet accumulation in tumour cells that protects against oxidative stress, and thus supports tumour progression.
1000 Sacherschließung
lokal oxidative stress
lokal breast cancer
lokal PLIN2
lokal LIPG
lokal TXNRD1
lokal endothelial lipase
lokal lipid droplets
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3374-6418|https://frl.publisso.de/adhoc/uri/Vm9zYmVjaywgU29uamE=|https://orcid.org/0000-0002-0276-2143|https://frl.publisso.de/adhoc/uri/R3JnYXMsIEthdGhhcmluYSAg|https://frl.publisso.de/adhoc/uri/TWFkamFyLCBLYXRyaW4=|https://frl.publisso.de/adhoc/uri/SGVsbHdpZywgQmlydGU=|https://frl.publisso.de/adhoc/uri/QWRhd3ksIEFsc2hhaW1h|https://frl.publisso.de/adhoc/uri/R2xvdHpiYWNoLCBBbm5pa2E=|https://frl.publisso.de/adhoc/uri/U3Rld2FydCwgSm9hbm5hIEQu|https://frl.publisso.de/adhoc/uri/TGVzamFrLCBNaWNoYWVsYSBTLg==|https://frl.publisso.de/adhoc/uri/RnJhbmNrZW5zdGVpbiwgRGVubmlz|https://frl.publisso.de/adhoc/uri/Q2xhdXMsIE1hcmVu|https://frl.publisso.de/adhoc/uri/SGF5ZW4sIEhlaWtvIA==|https://frl.publisso.de/adhoc/uri/U2Nocmlld2VyLCBBbGV4YW5kZXI=|https://frl.publisso.de/adhoc/uri/R2lhbm1vZW5hLCBLYXRocmlu|https://frl.publisso.de/adhoc/uri/VGhhbGVyLCBTb25qYQ==|https://frl.publisso.de/adhoc/uri/IFNjaG1pZHQsIE1hcmN1cw==|https://orcid.org/0000-0003-1210-5961|https://frl.publisso.de/adhoc/uri/UG9udMOpbiwgRnJlZHJpaw==|https://frl.publisso.de/adhoc/uri/TWFyZGlub2dsdSwgQWRpbA==|https://frl.publisso.de/adhoc/uri/WmhhbmcsIENoZW5n|https://frl.publisso.de/adhoc/uri/S8OkZmZlcmxlaW4sIEhlaWtvIFUu|https://orcid.org/0000-0001-5195-0995|https://frl.publisso.de/adhoc/uri/RnJhbmssIFNhxaFh|https://orcid.org/0000-0002-8947-440X|https://orcid.org/0000-0003-4414-1633|https://orcid.org/0000-0002-1427-5246
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. 01KU1216I
1000 Förderprogramm
  1. -
1000 Dateien
  1. LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer
    LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer 01KU1216I
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415600.rdf
1000 Erstellt am 2019-08-02T15:50:29.867+0200
1000 Erstellt von 254
1000 beschreibt frl:6415600
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 17:32:24 CET 2020
1000 Objekt bearb. Mon Aug 12 08:54:03 CEST 2019
1000 Vgl. frl:6415600
1000 Oai Id
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