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1000 Titel
  • Antidepressants and the Risk of Hemorrhagic Stroke in the Elderly: a Nested Case–Control Study
1000 Autor/in
  1. Schäfer, Wiebke |
  2. Princk, Christina |
  3. Kollhorst, Bianca |
  4. Schink, Tania |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-06-04
1000 Erschienen in
1000 Quellenangabe
  • 42(9):1081-1089
1000 FRL-Sammlung
1000 Embargo
  • 2020-06-04
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40264-019-00837-y |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs40264-019-00837-y#SupplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND AND PURPOSE: Selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed in the elderly due to a more favorable risk profile than other antidepressants (ADs). However, SSRIs are associated with an increased risk of gastrointestinal bleeding, while evidence on the risk of hemorrhagic stroke (HS) is limited. Therefore, we compared the risk of HS associated with the use of ADs in the elderly. METHODS: Based on data from the German Pharmacoepidemiological Research Database (GePaRD), a case–control study matched on age, sex, and health insurance provider, nested in a cohort of incident users of ADs ≥ 65 years of age was performed. Cases were identified from hospital discharge diagnoses, and exposure was identified from outpatient prescriptions. Multivariable conditional logistic regression was used to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Based on 4059 cases and 40,590 controls, an increased risk of HS was found in current use of SSRIs (OR 1.39, 95% CI 1.22–1.58), selective serotonin and noradrenaline reuptake inhibitors (1.69, 1.35–2.11), noradrenergic and specific serotonergic ADs (1.44, 1.22–1.69), and noradrenaline reuptake inhibitors (3.81, 1.54–9.43) compared with tri- and tetracyclic antidepressants. An increased risk of HS was seen in patients with a high baseline risk of bleeding and in patients with depression. The risk of HS varied between individual ADs. CONCLUSION: Our study shows that the use of medications inhibiting serotonin and/or noradrenaline reuptake increases the risk of HS in patients aged 65 years and older and that the risk varies across individual ADs.
1000 Sacherschließung
lokal serotonin reuptake inhibitors
lokal drug
lokal mortality
lokal case-fatality
lokal association
lokal depression
lokal cerebrovascular events
lokal patterns
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8284-448X|https://frl.publisso.de/adhoc/uri/UHJpbmNrLCBDaHJpc3RpbmE=|https://frl.publisso.de/adhoc/uri/S29sbGhvcnN0LCBCaWFuY2E=|https://orcid.org/0000-0002-0224-1866
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1000 Förderprogramm
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1000 Dateien
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1000 @id frl:6416489.rdf
1000 Erstellt am 2019-09-25T14:57:43.015+0200
1000 Erstellt von 266
1000 beschreibt frl:6416489
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Mon Mar 08 15:25:51 CET 2021
1000 Objekt bearb. Mon Mar 08 15:25:51 CET 2021
1000 Vgl. frl:6416489
1000 Oai Id
  1. oai:frl.publisso.de:frl:6416489 |
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