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Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis

  1. Borges do Nascimento, Israel Junior ORCID logo
  2. Cacic, Nensi
  3. Abdulazeem, Hebatullah ORCID logo
  4. von Groote, Thilo Caspar
  5. Jayarajah, Umesh ORCID logo
  6. Weerasekara, Ishanka ORCID logo
  7. Abdar Esfahani, Meisam ORCID logo
  8. Civile, Vinicius ORCID logo
  9. Marusic, Ana ORCID logo
  10. Jeroncic, Ana
  11. Carvas Junior, Nelson
  12. Poklepović Peričić, Tina ORCID logo
  13. Zakarija-Grkovic, Irena ORCID logo
  14. Meirelles Guimarães, Silvana Mangeon
  15. Bragazzi, Nicola ORCID logo
  16. Björklund, Maria ORCID logo
  17. Sofi-Mahmudi, Ahmad ORCID logo
  18. Altujjar, Mohammad
  19. Tian, Maoyi
  20. Cespedes Arcani, Diana Maria ORCID logo
  21. O'Mathúna, Dónal ORCID logo
  22. Marcolino, Milena ORCID logo

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1000 Titel
  • Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis
1000 Autor/in
  1. Borges do Nascimento, Israel Junior |
  2. Cacic, Nensi |
  3. Abdulazeem, Hebatullah |
  4. von Groote, Thilo Caspar |
  5. Jayarajah, Umesh |
  6. Weerasekara, Ishanka |
  7. Abdar Esfahani, Meisam |
  8. Civile, Vinicius |
  9. Marusic, Ana |
  10. Jeroncic, Ana |
  11. Carvas Junior, Nelson |
  12. Poklepović Peričić, Tina |
  13. Zakarija-Grkovic, Irena |
  14. Meirelles Guimarães, Silvana Mangeon |
  15. Bragazzi, Nicola |
  16. Björklund, Maria |
  17. Sofi-Mahmudi, Ahmad |
  18. Altujjar, Mohammad |
  19. Tian, Maoyi |
  20. Cespedes Arcani, Diana Maria |
  21. O'Mathúna, Dónal |
  22. Marcolino, Milena |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-30
1000 Erschienen in
1000 Quellenangabe
  • 9(4):941
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/jcm9040941 |
1000 Ergänzendes Material
  • https://www.mdpi.com/2077-0383/9/4/941#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%–99%; n = 4410), cough (61%, 95% CI 39%–81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%–55%; n = 3778), dyspnea (26%, 95% CI 12%–41%; n = 3700), headache in 12% (95% CI 4%–23%, n = 3598 patients), sore throat in 10% (95% CI 5%–17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%–17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83–1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54–45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%–1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal novel coronavirus
lokal scoping review
lokal meta-analysis
lokal SARS-CoV-2
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5240-0493|https://frl.publisso.de/adhoc/uri/Q2FjaWMsIE5lbnNp|https://orcid.org/0000-0002-4529-7114|https://frl.publisso.de/adhoc/uri/dm9uIEdyb290ZSwgVGhpbG8gQ2FzcGFy|https://orcid.org/0000-0002-0398-5197|https://orcid.org/0000-0002-8195-5057|https://orcid.org/0000-0001-6082-9169|https://orcid.org/0000-0002-1718-6281|https://orcid.org/0000-0001-6272-0917|https://frl.publisso.de/adhoc/uri/SmVyb25jaWMsIEFuYQ==|https://frl.publisso.de/adhoc/uri/Q2FydmFzIEp1bmlvciwgTmVsc29u|https://orcid.org/0000-0002-9686-5062|https://orcid.org/0000-0002-3618-6017|https://frl.publisso.de/adhoc/uri/TWVpcmVsbGVzIEd1aW1hcsOjZXMsIFNpbHZhbmEgTWFuZ2Vvbg==|https://orcid.org/0000-0001-8409-868X|https://orcid.org/0000-0001-8027-1297|https://orcid.org/0000-0001-6829-0823|https://frl.publisso.de/adhoc/uri/QWx0dWpqYXIsIE1vaGFtbWFk|https://frl.publisso.de/adhoc/uri/VGlhbiwgTWFveWk=|https://orcid.org/0000-0003-1979-9214|https://orcid.org/0000-0001-5331-3340|https://orcid.org/0000-0003-4278-3771
1000 Label
1000 Förderer
  1. Westfälische Wilhelms-Universität Münster |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Open Access Publication Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Westfälische Wilhelms-Universität Münster |
    1000 Förderprogramm Open Access Publication Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6420046.rdf
1000 Erstellt am 2020-04-14T14:57:30.107+0200
1000 Erstellt von 25
1000 beschreibt frl:6420046
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Apr 14 14:59:16 CEST 2020
1000 Objekt bearb. Tue Apr 14 14:59:00 CEST 2020
1000 Vgl. frl:6420046
1000 Oai Id
  1. oai:frl.publisso.de:frl:6420046 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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