Download
s41598-020-78039-1.pdf 1,03MB
WeightNameValue
1000 Titel
  • Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19
1000 Autor/in
  1. Spagnuolo, V. |
  2. Guffanti, M. |
  3. Galli, L. |
  4. Poli, A. |
  5. Querini, P. Rovere |
  6. Ripa, M. |
  7. Clementi, M. |
  8. Scarpellini, P. |
  9. Lazzarin, A. |
  10. Tresoldi, Moreno |
  11. Dagna, L. |
  12. Zangrillo, A. |
  13. Ciceri, F. |
  14. Castagna, A. |
  15. Andolina, A. |
  16. Redaelli, M. Baiardo |
  17. Baldissera, E. |
  18. Bigai, G. |
  19. Bigoloni, A. |
  20. Boffini, N. |
  21. Borio, G. |
  22. Bossolasco, S. |
  23. Bruzzesi, E. |
  24. Calabrò, M. G. |
  25. Calvisi, S. |
  26. Campochiaro, C. |
  27. Canetti, D. |
  28. Canti, V. |
  29. Castellani, J. |
  30. Castiglioni, B. |
  31. Cavalli, G. |
  32. Cavallo, L. |
  33. Cernuschi, M. |
  34. Chiurlo, M. |
  35. Cilla, M. |
  36. Cinel, E. |
  37. Cinque, P. |
  38. Conte, C. |
  39. Da Prat, V. |
  40. Danise, A. |
  41. De Lorenzo, R. |
  42. De Luca, G. |
  43. Dell’Acqua, A. |
  44. Dell’Acqua, R. |
  45. Torre, E. Della |
  46. Torre, L. Della |
  47. Di Terlizzi, G. |
  48. Dumea, I. |
  49. Farolfi, F. |
  50. Ferrante, M. |
  51. Frangi, C. |
  52. Fumagalli, L. |
  53. Gallina, G. |
  54. Germinario, B. |
  55. Gianotti, Nicola |
  56. Hasson, H. |
  57. Lalla, F. |
  58. LANDONI, Giovanni |
  59. Lanzillotta, M. |
  60. Voti, R. Li |
  61. Mastrangelo, A. |
  62. Messina, E. |
  63. Moizo, E. |
  64. Montagna, M. |
  65. Monti, G. |
  66. Morsica, G. |
  67. Muccini, C. |
  68. Nozza, S. |
  69. Oltolini, C. |
  70. Pascali, M. |
  71. Patrizi, A. |
  72. Pieri, M. |
  73. Prestifilippo, D. |
  74. Ramirez, Giuseppe Alvise |
  75. Ranzenigo, M. |
  76. Sapienza, J. |
  77. Sartorelli, S. |
  78. Seghi, F. |
  79. Tambussi, G. |
  80. Din, C. Tassan |
  81. Tomelleri, A. |
  82. Turi, S. |
  83. Uberti-Foppa, C. |
  84. Vinci, C. |
1000 Mitwirkende/r
  1. COVID-BioB study group |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-04
1000 Erschienen in
1000 Quellenangabe
  • 10:21291
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-020-78039-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718220/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO2/FiO2 ≤ 200 mmHg (45.8% vs 34.4% in steroids and non-steroids users, respectively; p = 0.023) or ≤ 100 mmHg (16.9% vs 12.7%; p = 0.027), and length of hospitalization (20 vs 14 days; p < 0.001). Time to negativization of nasopharyngeal swabs was similar in steroid and non-steroid users (p = 0.985). According to multivariate analysis, SARS-CoV-2 clearance was associated with age ≤ 70 years, a shorter duration of symptoms at admission, a baseline PaO2/FiO2 > 200 mmHg, and a lymphocyte count at admission > 1.0 × 109/L. SARS-CoV-2 clearance was not associated with corticosteroid use. Our study shows that delayed SARS-CoV-2 clearance in moderate/severe COVID-19 is associated with older age and a more severe disease, but not with an early use of corticosteroids.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Infectious diseases
lokal Viral infection
lokal Diseases
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U3BhZ251b2xvLCBWLg==|https://frl.publisso.de/adhoc/uri/R3VmZmFudGksIE0u|https://frl.publisso.de/adhoc/uri/R2FsbGksIEwu|https://frl.publisso.de/adhoc/uri/UG9saSwgQS4=|https://frl.publisso.de/adhoc/uri/UXVlcmluaSwgUC4gUm92ZXJl|https://frl.publisso.de/adhoc/uri/UmlwYSwgTS4=|https://frl.publisso.de/adhoc/uri/Q2xlbWVudGksIE0u|https://frl.publisso.de/adhoc/uri/U2NhcnBlbGxpbmksIFAu|https://frl.publisso.de/adhoc/uri/TGF6emFyaW4sIEEu|https://orcid.org/0000-0003-1541-6650|https://frl.publisso.de/adhoc/uri/RGFnbmEsIEwu|https://frl.publisso.de/adhoc/uri/WmFuZ3JpbGxvLCBBLg==|https://frl.publisso.de/adhoc/uri/Q2ljZXJpLCBGLg==|https://frl.publisso.de/adhoc/uri/IENhc3RhZ25hLCBBLg==|https://frl.publisso.de/adhoc/uri/QW5kb2xpbmEsIEEu|https://frl.publisso.de/adhoc/uri/UmVkYWVsbGksIE0uIEJhaWFyZG8=|https://frl.publisso.de/adhoc/uri/QmFsZGlzc2VyYSwgRS4=|https://frl.publisso.de/adhoc/uri/QmlnYWksIEcu|https://frl.publisso.de/adhoc/uri/Qmlnb2xvbmksIEEu|https://frl.publisso.de/adhoc/uri/Qm9mZmluaSwgTi4=|https://frl.publisso.de/adhoc/uri/Qm9yaW8sIEcu|https://frl.publisso.de/adhoc/uri/Qm9zc29sYXNjbywgUy4=|https://frl.publisso.de/adhoc/uri/QnJ1enplc2ksIEUu|https://frl.publisso.de/adhoc/uri/Q2FsYWJyw7IsIE0uIEcu|https://frl.publisso.de/adhoc/uri/Q2FsdmlzaSwgUy4=|https://frl.publisso.de/adhoc/uri/Q2FtcG9jaGlhcm8sIEMu|https://frl.publisso.de/adhoc/uri/Q2FuZXR0aSwgRC4=|https://frl.publisso.de/adhoc/uri/Q2FudGksIFYu|https://frl.publisso.de/adhoc/uri/Q2FzdGVsbGFuaSwgSi4=|https://frl.publisso.de/adhoc/uri/Q2FzdGlnbGlvbmksIEIu|https://frl.publisso.de/adhoc/uri/Q2F2YWxsaSwgRy4=|https://frl.publisso.de/adhoc/uri/IENhdmFsbG8sIEwu|https://frl.publisso.de/adhoc/uri/Q2VybnVzY2hpLCBNLg==|https://frl.publisso.de/adhoc/uri/Q2hpdXJsbywgTS4=|https://frl.publisso.de/adhoc/uri/Q2lsbGEsIE0u|https://frl.publisso.de/adhoc/uri/Q2luZWwsIEUu|https://frl.publisso.de/adhoc/uri/Q2lucXVlLCBQLg==|https://frl.publisso.de/adhoc/uri/Q29udGUsIEMu|https://frl.publisso.de/adhoc/uri/RGEgUHJhdCwgVi4=|https://frl.publisso.de/adhoc/uri/RGFuaXNlLCBBLg==|https://frl.publisso.de/adhoc/uri/RGUgTG9yZW56bywgUi4=|https://frl.publisso.de/adhoc/uri/RGUgTHVjYSwgRy4=|https://frl.publisso.de/adhoc/uri/RGVsbOKAmUFjcXVhLCBBLg==|https://frl.publisso.de/adhoc/uri/RGVsbOKAmUFjcXVhLCBSLg==|https://frl.publisso.de/adhoc/uri/VG9ycmUsIEUuIERlbGxh|https://frl.publisso.de/adhoc/uri/VG9ycmUsIEwuIERlbGxh|https://frl.publisso.de/adhoc/uri/RGkgVGVybGl6emksIEcu|https://frl.publisso.de/adhoc/uri/RHVtZWEsIEku|https://frl.publisso.de/adhoc/uri/RmFyb2xmaSwgRi4=|https://frl.publisso.de/adhoc/uri/RmVycmFudGUsIE0u|https://frl.publisso.de/adhoc/uri/RnJhbmdpLCBDLg==|https://frl.publisso.de/adhoc/uri/RnVtYWdhbGxpLCBMLg==|https://frl.publisso.de/adhoc/uri/R2FsbGluYSwgRy4=|https://frl.publisso.de/adhoc/uri/R2VybWluYXJpbywgQi4=|https://orcid.org/0000-0002-7182-5080|https://frl.publisso.de/adhoc/uri/SGFzc29uLCBILg==|https://frl.publisso.de/adhoc/uri/TGFsbGEsIEYu|https://orcid.org/0000-0002-8594-5980|https://frl.publisso.de/adhoc/uri/TGFuemlsbG90dGEsIE0u|https://frl.publisso.de/adhoc/uri/Vm90aSwgUi4gTGk=|https://frl.publisso.de/adhoc/uri/TWFzdHJhbmdlbG8sIEEu|https://frl.publisso.de/adhoc/uri/TWVzc2luYSwgRS4=|https://frl.publisso.de/adhoc/uri/TW9pem8sIEUu|https://frl.publisso.de/adhoc/uri/TW9udGFnbmEsIE0u|https://frl.publisso.de/adhoc/uri/TW9udGksIEcu|https://frl.publisso.de/adhoc/uri/TW9yc2ljYSwgRy4=|https://frl.publisso.de/adhoc/uri/TXVjY2luaSwgQy4=|https://frl.publisso.de/adhoc/uri/IE5venphLCBTLg==|https://frl.publisso.de/adhoc/uri/T2x0b2xpbmksIEMu|https://frl.publisso.de/adhoc/uri/UGFzY2FsaSwgTS4=|https://frl.publisso.de/adhoc/uri/UGF0cml6aSwgQS4=|https://frl.publisso.de/adhoc/uri/UGllcmksIE0u|https://frl.publisso.de/adhoc/uri/UHJlc3RpZmlsaXBwbywgRC4=|https://orcid.org/0000-0002-2889-366X|https://frl.publisso.de/adhoc/uri/UmFuemVuaWdvLCBNLg==|https://frl.publisso.de/adhoc/uri/U2FwaWVuemEsIEou|https://frl.publisso.de/adhoc/uri/U2FydG9yZWxsaSwgUy4=|https://frl.publisso.de/adhoc/uri/U2VnaGksIEYu|https://frl.publisso.de/adhoc/uri/VGFtYnVzc2ksIEcu|https://frl.publisso.de/adhoc/uri/RGluLCBDLiBUYXNzYW4=|https://frl.publisso.de/adhoc/uri/VG9tZWxsZXJpLCBBLg==|https://frl.publisso.de/adhoc/uri/VHVyaSwgUy4=|https://frl.publisso.de/adhoc/uri/VWJlcnRpLUZvcHBhLCBDLg==|https://frl.publisso.de/adhoc/uri/VmluY2ksIEMu|https://frl.publisso.de/adhoc/uri/Q09WSUQtQmlvQiBzdHVkeSBncm91cA==
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6425839.rdf
1000 Erstellt am 2021-02-25T12:44:23.304+0100
1000 Erstellt von 5
1000 beschreibt frl:6425839
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Mar 16 07:48:13 CET 2021
1000 Objekt bearb. Tue Mar 16 07:44:21 CET 2021
1000 Vgl. frl:6425839
1000 Oai Id
  1. oai:frl.publisso.de:frl:6425839 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source