A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging

  1. Soch, Joram ORCID logo
  2. Richter, Anni ORCID logo
  3. Schütze, Hartmut
  4. Kizilirmak, Jasmin ORCID logo
  5. Assmann, Anne
  6. Behnisch, Gusalija
  7. Feldhoff, Hannah
  8. Fischer, Larissa
  9. Heil, Julius
  10. Knopf, Lea
  11. Merkel, Christian
  12. Raschick, Matthias
  13. Schietke, Clara-Johanna
  14. Schult, Annika
  15. Seidenbecher, Constanze ORCID logo
  16. Yakupov, Renat
  17. Ziegler, Gabriel
  18. Wiltfang, Jens
  19. Düzel, Emrah
  20. Schott, Björn ORCID logo

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Human Brain Mapping - 2021 - Soch - A comprehensive score reflecting memory%u2010related fMRI activations and deactivations as.pdf 4,13MB
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1000 Titel
  • A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
1000 Autor/in
  1. Soch, Joram |
  2. Richter, Anni |
  3. Schütze, Hartmut |
  4. Kizilirmak, Jasmin |
  5. Assmann, Anne |
  6. Behnisch, Gusalija |
  7. Feldhoff, Hannah |
  8. Fischer, Larissa |
  9. Heil, Julius |
  10. Knopf, Lea |
  11. Merkel, Christian |
  12. Raschick, Matthias |
  13. Schietke, Clara-Johanna |
  14. Schult, Annika |
  15. Seidenbecher, Constanze |
  16. Yakupov, Renat |
  17. Ziegler, Gabriel |
  18. Wiltfang, Jens |
  19. Düzel, Emrah |
  20. Schott, Björn |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-16
1000 Erschienen in
1000 Quellenangabe
  • 42(14):4478-4496
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/hbm.25559 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410542/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/10.1002/hbm.25559#hbm25559-app-0001-title |
  • https://onlinelibrary.wiley.com/doi/10.1002/hbm.25559#hbm25559-app-0002-title |
  • https://onlinelibrary.wiley.com/doi/10.1002/hbm.25559#hbm25559-app-0003-title |
  • https://onlinelibrary.wiley.com/doi/10.1002/hbm.25559#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust age-group-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.
1000 Sacherschließung
lokal episodic memory
lokal memory impairment
lokal fMRI
lokal subsequent memory effect
lokal cognitive aging
lokal hippocampus
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8879-5666|https://orcid.org/0000-0001-9681-6298|https://frl.publisso.de/adhoc/uri/U2Now7x0emUsIEhhcnRtdXQ=|https://orcid.org/0000-0002-5938-3523|https://frl.publisso.de/adhoc/uri/QXNzbWFubiwgQW5uZQ==|https://frl.publisso.de/adhoc/uri/QmVobmlzY2gsIEd1c2FsaWph|https://frl.publisso.de/adhoc/uri/RmVsZGhvZmYsIEhhbm5haA==|https://frl.publisso.de/adhoc/uri/RmlzY2hlciwgTGFyaXNzYQ==|https://frl.publisso.de/adhoc/uri/SGVpbCwgSnVsaXVz|https://frl.publisso.de/adhoc/uri/S25vcGYsIExlYQ==|https://frl.publisso.de/adhoc/uri/TWVya2VsLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/UmFzY2hpY2ssIE1hdHRoaWFz|https://frl.publisso.de/adhoc/uri/U2NoaWV0a2UsIENsYXJhLUpvaGFubmE=|https://frl.publisso.de/adhoc/uri/U2NodWx0LCBBbm5pa2E=|https://orcid.org/0000-0002-7433-2716|https://frl.publisso.de/adhoc/uri/WWFrdXBvdiwgUmVuYXQ=|https://frl.publisso.de/adhoc/uri/WmllZ2xlciwgR2FicmllbA==|https://frl.publisso.de/adhoc/uri/V2lsdGZhbmcsIEplbnM=|https://frl.publisso.de/adhoc/uri/RMO8emVsLCBFbXJhaA==|https://orcid.org/0000-0002-8237-4481
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. European Regional Development Fund |
  3. Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt |
  4. Projekt DEAL |
1000 Fördernummer
  1. RI 2964-1; SFB 1436, TP A05; SFB 779, TP A08
  2. -
  3. -
  4. -
1000 Förderprogramm
  1. -
  2. Autonomy in Old Age
  3. -
  4. Open Access Funding
1000 Dateien
  1. A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
    A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer RI 2964-1; SFB 1436, TP A05; SFB 779, TP A08
  2. 1000 joinedFunding-child
    1000 Förderer European Regional Development Fund |
    1000 Förderprogramm Autonomy in Old Age
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access Funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6430876.rdf
1000 Erstellt am 2022-01-04T10:01:12.154+0100
1000 Erstellt von 242
1000 beschreibt frl:6430876
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri May 13 14:22:04 CEST 2022
1000 Objekt bearb. Fri May 13 14:22:03 CEST 2022
1000 Vgl. frl:6430876
1000 Oai Id
  1. oai:frl.publisso.de:frl:6430876 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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