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1000 Titel
  • Ecological Specialization and Evolutionary Reticulation in Extant Hyaenidae
1000 Autor/in
  1. Westbury, Michael |
  2. Le Duc, Diana |
  3. Duchêne, David A |
  4. Krishnan, Arunkumar |
  5. Prost, Stefan |
  6. Rutschmann, Sereina |
  7. Grau, Jose H |
  8. Dalén, Love |
  9. Weyrich, Alexandra |
  10. Norén, Karin |
  11. Werdelin, Lars |
  12. Dalerum, Fredrik |
  13. Schöneberg, Torsten |
  14. Hofreiter, Michael |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-24
1000 Erschienen in
1000 Quellenangabe
  • 38(9):3884-3897
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1093/molbev/msab055 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382907/ |
1000 Ergänzendes Material
  • https://academic.oup.com/mbe/article/38/9/3884/6149117#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • During the Miocene, Hyaenidae was a highly diverse family of Carnivora that has since been severely reduced to four species: the bone-cracking spotted, striped, and brown hyenas, and the specialized insectivorous aardwolf. Previous studies investigated the evolutionary histories of the spotted and brown hyenas, but little is known about the remaining two species. Moreover, the genomic underpinnings of scavenging and insectivory, defining traits of the extant species, remain elusive. Here, we generated an aardwolf genome and analyzed it together with the remaining three species to reveal their evolutionary relationships, genomic underpinnings of their scavenging and insectivorous lifestyles, and their respective genetic diversities and demographic histories. High levels of phylogenetic discordance suggest gene flow between the aardwolf lineage and the ancestral brown/striped hyena lineage. Genes related to immunity and digestion in the bone-cracking hyenas and craniofacial development in the aardwolf showed the strongest signals of selection, suggesting putative key adaptations to carrion and termite feeding, respectively. A family-wide expansion in olfactory receptor genes suggests that an acute sense of smell was a key early adaptation. Finally, we report very low levels of genetic diversity within the brown and striped hyenas despite no signs of inbreeding, putatively linked to their similarly slow decline in effective population size over the last ∼2 million years. High levels of genetic diversity and more stable population sizes through time are seen in the spotted hyena and aardwolf. Taken together, our findings highlight how ecological specialization can impact the evolutionary history, demographics, and adaptive genetic changes of an evolutionary lineage.
1000 Sacherschließung
lokal genome
lokal genetic diversity
lokal adaptation
lokal phylogenomics
lokal comparative genomics
lokal hyena
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0478-3930|https://frl.publisso.de/adhoc/uri/TGUgRHVjLCBEaWFuYQ==|https://frl.publisso.de/adhoc/uri/RHVjaMOqbmUsIERhdmlkIEE=|https://frl.publisso.de/adhoc/uri/S3Jpc2huYW4sIEFydW5rdW1hcg==|https://orcid.org/0000-0002-6229-3596|https://frl.publisso.de/adhoc/uri/UnV0c2NobWFubiwgU2VyZWluYQ==|https://frl.publisso.de/adhoc/uri/R3JhdSwgSm9zZSBI|https://frl.publisso.de/adhoc/uri/RGFsw6luLCBMb3Zl|https://orcid.org/0000-0002-6944-1854|https://frl.publisso.de/adhoc/uri/Tm9yw6luLCBLYXJpbg==|https://frl.publisso.de/adhoc/uri/V2VyZGVsaW4sIExhcnM=|https://frl.publisso.de/adhoc/uri/RGFsZXJ1bSwgRnJlZHJpaw==|https://frl.publisso.de/adhoc/uri/U2Now7ZuZWJlcmcsIFRvcnN0ZW4=|https://frl.publisso.de/adhoc/uri/SG9mcmVpdGVyLCBNaWNoYWVs
1000 Label
1000 Förderer
  1. Swedish National Genomics Infrastructure |
  2. Vetenskapsrådet |
  3. Knut och Alice Wallenbergs Stiftelse |
  4. Uppsala Multidisciplinary Center for Advanced Computational Science |
  5. European Research Council |
  6. Australian Research Council |
  7. Medizinische Fakultät, Universität Leipzig |
  8. Leibniz Competition Fund |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. 310763
  6. DE190100544
  7. -
  8. SAW-2018-IZW-3-EpiRank
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. Clinician Scientist Programm, Medizinische Fakultät der Universität Leipzig
  8. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Swedish National Genomics Infrastructure |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Vetenskapsrådet |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Knut och Alice Wallenbergs Stiftelse |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Uppsala Multidisciplinary Center for Advanced Computational Science |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer European Research Council |
    1000 Förderprogramm -
    1000 Fördernummer 310763
  6. 1000 joinedFunding-child
    1000 Förderer Australian Research Council |
    1000 Förderprogramm -
    1000 Fördernummer DE190100544
  7. 1000 joinedFunding-child
    1000 Förderer Medizinische Fakultät, Universität Leipzig |
    1000 Förderprogramm Clinician Scientist Programm, Medizinische Fakultät der Universität Leipzig
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer Leibniz Competition Fund |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2018-IZW-3-EpiRank
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6434307.rdf
1000 Erstellt am 2022-07-26T15:56:10.247+0200
1000 Erstellt von 218
1000 beschreibt frl:6434307
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Fri Aug 05 11:37:56 CEST 2022
1000 Objekt bearb. Fri Aug 05 11:36:28 CEST 2022
1000 Vgl. frl:6434307
1000 Oai Id
  1. oai:frl.publisso.de:frl:6434307 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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