Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

  1. Jost, Stefanie T.
  2. Visser-Vandewalle, Veerle
  3. Rizos, Alexandra
  4. Loehrer, Philipp Alexander ORCID logo
  5. Silverdale, Monty
  6. Evans, Julian
  7. Samuel, Michael
  8. Petry-Schmelzer, Jan Niklas
  9. Sauerbier, Anna
  10. Gronostay, Alexandra
  11. Barbe, Michael T.
  12. Fink, Gereon R. ORCID logo
  13. Ashkan, Keyoumars
  14. Antonini, Angelo
  15. Martinez-Martin, Pablo
  16. Ray Chaudhuri, K ORCID logo
  17. Timmermann, Lars
  18. Dafsari, Haidar ORCID logo
  19. Bhidayasiri, Roongroj
  20. Falup-Pecurariu, Cristian
  21. Jeon, Beomseok
  22. Leta, Valentina
  23. Borghammer, Per
  24. Odin, Per
  25. Schrag, Anette
  26. Storch, Alexander
  27. Violante, Mayela Rodriguez
  28. Weintraub, Daniel
  29. Adler, Charles
  30. Barone, Paolo
  31. Brooks, David J.
  32. Brown, Richard
  33. Cantillon, Marc
  34. Carroll, Camille
  35. Coelho, Miguel
  36. Henriksen, Tove
  37. Hu, Michele
  38. Jenner, Peter
  39. Kramberger, Milica
  40. Kumar, Padma
  41. Kurtis, Mónica
  42. Lewis, Simon
  43. Litvan, Irene
  44. Lyons, Kelly
  45. Martino, Davide
  46. Masellis, Mario
  47. Mochizuki, Hideki
  48. Morley, James F.
  49. Nirenberg, Melissa
  50. Pagonabarraga, Javier
  51. Panicker, Jalesh
  52. Pavese, Nicola
  53. Pekkonen, Eero
  54. Postuma, Ron
  55. Rosales, Raymond
  56. Schapira, Anthony
  57. Simuni, Tanya
  58. Stocchi, Fabrizio
  59. Subramanian, Indu
  60. Tagliati, Michele
  61. Tinazzi, Michele
  62. Toledo, Jon
  63. Tsuboi, Yoshio
  64. Walker, Richard

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1000 Titel
  • Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
1000 Autor/in
  1. Jost, Stefanie T. |
  2. Visser-Vandewalle, Veerle |
  3. Rizos, Alexandra |
  4. Loehrer, Philipp Alexander |
  5. Silverdale, Monty |
  6. Evans, Julian |
  7. Samuel, Michael |
  8. Petry-Schmelzer, Jan Niklas |
  9. Sauerbier, Anna |
  10. Gronostay, Alexandra |
  11. Barbe, Michael T. |
  12. Fink, Gereon R. |
  13. Ashkan, Keyoumars |
  14. Antonini, Angelo |
  15. Martinez-Martin, Pablo |
  16. Ray Chaudhuri, K |
  17. Timmermann, Lars |
  18. Dafsari, Haidar |
  19. Bhidayasiri, Roongroj |
  20. Falup-Pecurariu, Cristian |
  21. Jeon, Beomseok |
  22. Leta, Valentina |
  23. Borghammer, Per |
  24. Odin, Per |
  25. Schrag, Anette |
  26. Storch, Alexander |
  27. Violante, Mayela Rodriguez |
  28. Weintraub, Daniel |
  29. Adler, Charles |
  30. Barone, Paolo |
  31. Brooks, David J. |
  32. Brown, Richard |
  33. Cantillon, Marc |
  34. Carroll, Camille |
  35. Coelho, Miguel |
  36. Henriksen, Tove |
  37. Hu, Michele |
  38. Jenner, Peter |
  39. Kramberger, Milica |
  40. Kumar, Padma |
  41. Kurtis, Mónica |
  42. Lewis, Simon |
  43. Litvan, Irene |
  44. Lyons, Kelly |
  45. Martino, Davide |
  46. Masellis, Mario |
  47. Mochizuki, Hideki |
  48. Morley, James F. |
  49. Nirenberg, Melissa |
  50. Pagonabarraga, Javier |
  51. Panicker, Jalesh |
  52. Pavese, Nicola |
  53. Pekkonen, Eero |
  54. Postuma, Ron |
  55. Rosales, Raymond |
  56. Schapira, Anthony |
  57. Simuni, Tanya |
  58. Stocchi, Fabrizio |
  59. Subramanian, Indu |
  60. Tagliati, Michele |
  61. Tinazzi, Michele |
  62. Toledo, Jon |
  63. Tsuboi, Yoshio |
  64. Walker, Richard |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-08
1000 Erschienen in
1000 Quellenangabe
  • 7(1):48
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41531-021-00174-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187358/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable 'QoL responders'/'non-responders'. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as 'QoL non-responders'. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as 'difficulties experiencing pleasure' and 'problems sustaining concentration'. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.
1000 Sacherschließung
lokal Article
lokal Quality of life
lokal Parkinson's disease
1000 Liste der Beteiligten
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