Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool

  1. Permanyer, Marc
  2. Bošnjak, Berislav ORCID logo
  3. Glage, Silke
  4. Friedrichsen, Michaela
  5. Floess, Stefan
  6. Huehn, Jochen ORCID logo
  7. Patzer, Gwendolyn E.
  8. Odak, Ivan ORCID logo
  9. Eckert, Nadine
  10. Zargari, Razieh
  11. Ospina-Quintero, Laura
  12. Georgiev, Hristo ORCID logo
  13. Förster, Reinhold

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1000 Titel
  • Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool
1000 Autor/in
  1. Permanyer, Marc |
  2. Bošnjak, Berislav |
  3. Glage, Silke |
  4. Friedrichsen, Michaela |
  5. Floess, Stefan |
  6. Huehn, Jochen |
  7. Patzer, Gwendolyn E. |
  8. Odak, Ivan |
  9. Eckert, Nadine |
  10. Zargari, Razieh |
  11. Ospina-Quintero, Laura |
  12. Georgiev, Hristo |
  13. Förster, Reinhold |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-06
1000 Erschienen in
1000 Quellenangabe
  • 18(2):398-414
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41423-020-00599-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027001/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under noninflammatory conditions, Cd25
1000 Sacherschließung
lokal Forkhead Transcription Factors/metabolism [MeSH]
lokal Female [MeSH]
lokal Mutation [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Colitis/pathology [MeSH]
lokal Forkhead Transcription Factors/genetics [MeSH]
lokal T-Lymphocytes, Regulatory/immunology [MeSH]
lokal Colitis/immunology [MeSH]
lokal Treg heterogeneity
lokal Animals [MeSH]
lokal Immunosuppression Therapy [MeSH]
lokal Interleukin-2/metabolism [MeSH]
lokal Mice [MeSH]
lokal Article
lokal Colitis/metabolism [MeSH]
lokal Male [MeSH]
lokal Interleukin-2 Receptor alpha Subunit/metabolism [MeSH]
lokal Signal Transduction [MeSH]
lokal scRNA sequencing
lokal IL-2R signaling
lokal Homeostasis [MeSH]
lokal Regulatory T cells
lokal Interleukin-2 Receptor alpha Subunit/genetics [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGVybWFueWVyLCBNYXJj|https://orcid.org/0000-0003-3374-7488|https://frl.publisso.de/adhoc/uri/R2xhZ2UsIFNpbGtl|https://frl.publisso.de/adhoc/uri/RnJpZWRyaWNoc2VuLCBNaWNoYWVsYQ==|https://frl.publisso.de/adhoc/uri/RmxvZXNzLCBTdGVmYW4=|https://orcid.org/0000-0001-8071-1379|https://frl.publisso.de/adhoc/uri/UGF0emVyLCBHd2VuZG9seW4gRS4=|https://orcid.org/0000-0003-0408-5091|https://frl.publisso.de/adhoc/uri/RWNrZXJ0LCBOYWRpbmU=|https://frl.publisso.de/adhoc/uri/WmFyZ2FyaSwgUmF6aWVo|https://frl.publisso.de/adhoc/uri/T3NwaW5hLVF1aW50ZXJvLCBMYXVyYQ==|https://orcid.org/0000-0003-1369-960X|https://frl.publisso.de/adhoc/uri/RsO2cnN0ZXIsIFJlaW5ob2xk
1000 Hinweis
  • DeepGreen-ID: 6fe9e4b1065641ec913536e372772427 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
1000 Objektart article
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1000 @id frl:6442848.rdf
1000 Erstellt am 2023-04-26T15:56:30.437+0200
1000 Erstellt von 322
1000 beschreibt frl:6442848
1000 Zuletzt bearbeitet 2023-10-19T13:30:55.362+0200
1000 Objekt bearb. Thu Oct 19 13:30:55 CEST 2023
1000 Vgl. frl:6442848
1000 Oai Id
  1. oai:frl.publisso.de:frl:6442848 |
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