Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients

  1. Bethge, Wolfgang ORCID logo
  2. Eyrich, Matthias ORCID logo
  3. Mielke, Stephan ORCID logo
  4. Meisel, Roland ORCID logo
  5. Niederwieser, Dietger ORCID logo
  6. Schlegel, Paul G.
  7. Schulz, Ansgar ORCID logo
  8. Greil, Johann
  9. Bunjes, Donald
  10. Brecht, Arne
  11. Kuball, Jurgen ORCID logo
  12. Schumm, Michael
  13. Vucinic, Vladan
  14. Wiesneth, Markus
  15. Bonig, Halvard
  16. Westinga, Kasper
  17. Biedermann, Stefanie
  18. Holtkamp, Silke
  19. Karitzky, Sandra
  20. Malchow, Michaela
  21. Siewert, Christiane
  22. Handgretinger, Rupert
  23. Lang, Peter ORCID logo

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1000 Titel
  • Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients
1000 Autor/in
  1. Bethge, Wolfgang |
  2. Eyrich, Matthias |
  3. Mielke, Stephan |
  4. Meisel, Roland |
  5. Niederwieser, Dietger |
  6. Schlegel, Paul G. |
  7. Schulz, Ansgar |
  8. Greil, Johann |
  9. Bunjes, Donald |
  10. Brecht, Arne |
  11. Kuball, Jurgen |
  12. Schumm, Michael |
  13. Vucinic, Vladan |
  14. Wiesneth, Markus |
  15. Bonig, Halvard |
  16. Westinga, Kasper |
  17. Biedermann, Stefanie |
  18. Holtkamp, Silke |
  19. Karitzky, Sandra |
  20. Malchow, Michaela |
  21. Siewert, Christiane |
  22. Handgretinger, Rupert |
  23. Lang, Peter |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-24
1000 Erschienen in
1000 Quellenangabe
  • 57(3):423-430
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41409-021-01551-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702395/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depleted peripheral blood stem cells from haploidentical family donors after a reduced-intensity conditioning with fludarabine, thiotepa, and melphalan. Thirty pediatric and 30 adult patients with acute leukemia (n = 43), myelodysplastic or myeloproliferative syndrome (n = 6), multiple myeloma (n = 1), solid tumors (n = 6), and non-malignant disorders (n = 4) were enrolled. TCR αβ/CD19-depleted grafts prepared decentrally at six manufacturing sites contained a median of 12.1 × 10
1000 Sacherschließung
lokal Transplantation Conditioning/methods [MeSH]
lokal Adult [MeSH]
lokal Lymphocyte Depletion/methods [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Leukemia, Myeloid, Acute/complications [MeSH]
lokal Bone marrow transplantation
lokal Article
lokal Receptors, Antigen, T-Cell, alpha-beta [MeSH]
lokal Graft vs Host Disease/etiology [MeSH]
lokal Haematological diseases
lokal Antigens, CD19 [MeSH]
lokal Hematopoietic Stem Cell Transplantation/methods [MeSH]
lokal Leukemia, Myeloid, Acute/therapy [MeSH]
lokal Child [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6052-2618|https://orcid.org/0000-0002-8099-5903|https://orcid.org/0000-0002-8325-9215|https://orcid.org/0000-0001-5230-0628|https://orcid.org/0000-0002-4737-1103|https://frl.publisso.de/adhoc/uri/U2NobGVnZWwsIFBhdWwgRy4=|https://orcid.org/0000-0002-7798-7996|https://frl.publisso.de/adhoc/uri/R3JlaWwsIEpvaGFubg==|https://frl.publisso.de/adhoc/uri/QnVuamVzLCBEb25hbGQ=|https://frl.publisso.de/adhoc/uri/QnJlY2h0LCBBcm5l|https://orcid.org/0000-0002-3914-7806|https://frl.publisso.de/adhoc/uri/U2NodW1tLCBNaWNoYWVs|https://frl.publisso.de/adhoc/uri/VnVjaW5pYywgVmxhZGFu|https://frl.publisso.de/adhoc/uri/V2llc25ldGgsIE1hcmt1cw==|https://frl.publisso.de/adhoc/uri/Qm9uaWcsIEhhbHZhcmQ=|https://frl.publisso.de/adhoc/uri/V2VzdGluZ2EsIEthc3Blcg==|https://frl.publisso.de/adhoc/uri/QmllZGVybWFubiwgU3RlZmFuaWU=|https://frl.publisso.de/adhoc/uri/SG9sdGthbXAsIFNpbGtl|https://frl.publisso.de/adhoc/uri/S2FyaXR6a3ksIFNhbmRyYQ==|https://frl.publisso.de/adhoc/uri/TWFsY2hvdywgTWljaGFlbGE=|https://frl.publisso.de/adhoc/uri/U2lld2VydCwgQ2hyaXN0aWFuZQ==|https://frl.publisso.de/adhoc/uri/SGFuZGdyZXRpbmdlciwgUnVwZXJ0|https://orcid.org/0000-0001-7737-2142
1000 Hinweis
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1000 Erstellt am 2023-04-26T16:08:40.122+0200
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1000 Zuletzt bearbeitet Thu Oct 19 13:35:34 CEST 2023
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