Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

  1. Pabel, Steffen
  2. Reetz, Florian
  3. Dybkova, Nataliya
  4. Shomroni, Orr
  5. Salinas, Gabriela
  6. Mustroph, Julian
  7. Hammer, Karin P.
  8. Hasenfuss, Gerd
  9. Hamdani, Nazha
  10. Maier, Lars S.
  11. Streckfuss-Bömeke, Katrin
  12. Sossalla, Samuel ORCID logo

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WeightNameValue
1000 Titel
  • Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes
1000 Autor/in
  1. Pabel, Steffen |
  2. Reetz, Florian |
  3. Dybkova, Nataliya |
  4. Shomroni, Orr |
  5. Salinas, Gabriela |
  6. Mustroph, Julian |
  7. Hammer, Karin P. |
  8. Hasenfuss, Gerd |
  9. Hamdani, Nazha |
  10. Maier, Lars S. |
  11. Streckfuss-Bömeke, Katrin |
  12. Sossalla, Samuel |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-10-09
1000 Erschienen in
1000 Quellenangabe
  • 98(12):1689-1700
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-020-01989-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679329/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The SGLT2 inhibitor empagliflozin improved cardiovascular outcomes in patients with diabetes. As the cardiac mechanisms remain elusive, we investigated the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner. IPSC from 3 donors, differentiated into pure iPSC-CM (4 differentiations), were treated with a clinically relevant concentration of empagliflozin (0.5 μmol/l) or vehicle control. Treatment, data acquisition, and analysis were conducted externally blinded. Epifluorescence microscopy measurements in iPSC-CM showed that empagliflozin has neutral effects on Ca
1000 Sacherschließung
lokal Calcium/metabolism [MeSH]
lokal Induced Pluripotent Stem Cells/cytology [MeSH]
lokal Humans [MeSH]
lokal Action Potentials/drug effects [MeSH]
lokal Benzhydryl Compounds/pharmacology [MeSH]
lokal iPSC-CM
lokal Cell Differentiation [MeSH]
lokal Glucosides/pharmacology [MeSH]
lokal Original Article
lokal Myocytes, Cardiac/physiology [MeSH]
lokal Myocytes, Cardiac/cytology [MeSH]
lokal Sarcoplasmic Reticulum/metabolism [MeSH]
lokal Excitation Contraction Coupling/drug effects [MeSH]
lokal Empagliflozin
lokal Sodium-Glucose Transporter 2 Inhibitors/pharmacology [MeSH]
lokal Electrophysiology
lokal Myocytes, Cardiac/drug effects [MeSH]
lokal Cells, Cultured [MeSH]
lokal EC-coupling
lokal Sarcoplasmic Reticulum/drug effects [MeSH]
lokal Calcium Signaling/drug effects [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGFiZWwsIFN0ZWZmZW4=|https://frl.publisso.de/adhoc/uri/UmVldHosIEZsb3JpYW4=|https://frl.publisso.de/adhoc/uri/RHlia292YSwgTmF0YWxpeWE=|https://frl.publisso.de/adhoc/uri/U2hvbXJvbmksIE9ycg==|https://frl.publisso.de/adhoc/uri/U2FsaW5hcywgR2FicmllbGE=|https://frl.publisso.de/adhoc/uri/TXVzdHJvcGgsIEp1bGlhbg==|https://frl.publisso.de/adhoc/uri/SGFtbWVyLCBLYXJpbiBQLg==|https://frl.publisso.de/adhoc/uri/SGFzZW5mdXNzLCBHZXJk|https://frl.publisso.de/adhoc/uri/SGFtZGFuaSwgTmF6aGE=|https://frl.publisso.de/adhoc/uri/TWFpZXIsIExhcnMgUy4=|https://frl.publisso.de/adhoc/uri/U3RyZWNrZnVzcy1Cw7ZtZWtlLCBLYXRyaW4=|https://orcid.org/0000-0001-8034-2673
1000 Hinweis
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1000 Erstellt am 2023-04-26T17:00:57.564+0200
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1000 Zuletzt bearbeitet Thu Oct 19 13:56:06 CEST 2023
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