USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

  1. Prokakis, Dr. rer. nat. Evangelos ORCID logo
  2. Dyas, Anna
  3. Grün, Regina
  4. Fritzsche, Sonja ORCID logo
  5. Bedi, Upasana
  6. Kazerouni, Zahra B.
  7. Kosinsky, Robyn Laura ORCID logo
  8. Johnsen, Steven ORCID logo
  9. Wegwitz, Florian ORCID logo

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WeightNameValue
1000 Titel
  • USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response
1000 Autor/in
  1. Prokakis, Dr. rer. nat. Evangelos |
  2. Dyas, Anna |
  3. Grün, Regina |
  4. Fritzsche, Sonja |
  5. Bedi, Upasana |
  6. Kazerouni, Zahra B. |
  7. Kosinsky, Robyn Laura |
  8. Johnsen, Steven |
  9. Wegwitz, Florian |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-05-18
1000 Erschienen in
1000 Quellenangabe
  • 40(23):4004-4018
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41388-021-01814-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195738/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called 'death-from-cancer' signature predicting therapy failure in cancer patients. However, the importance and functional role of USP22 in different types and subtypes of cancer remain largely unknown. In the present study, we leveraged human cell lines and genetic mouse models to investigate the role of USP22 in HER2-driven breast cancer (HER2
1000 Sacherschließung
lokal Cancer models
lokal Cell Line, Tumor [MeSH]
lokal Receptor, ErbB-2/metabolism [MeSH]
lokal Breast cancer
lokal Databases, Genetic [MeSH]
lokal Receptor, ErbB-2/genetics [MeSH]
lokal Ubiquitylation
lokal Mice, Transgenic [MeSH]
lokal Unfolded Protein Response [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Breast Neoplasms/pathology [MeSH]
lokal Endoplasmic Reticulum Stress [MeSH]
lokal Ubiquitin Thiolesterase/metabolism [MeSH]
lokal Female [MeSH]
lokal Humans [MeSH]
lokal Breast Neoplasms/genetics [MeSH]
lokal Endoplasmic reticulum
lokal Breast Neoplasms/metabolism [MeSH]
lokal Animals [MeSH]
lokal Mice, Knockout [MeSH]
lokal Survival Rate [MeSH]
lokal Mice [MeSH]
lokal Article
lokal Prognosis [MeSH]
lokal Ubiquitin Thiolesterase/genetics [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9297-1821|https://frl.publisso.de/adhoc/uri/RHlhcywgQW5uYQ==|https://frl.publisso.de/adhoc/uri/R3LDvG4sIFJlZ2luYQ==|https://orcid.org/0000-0003-3335-3534|https://frl.publisso.de/adhoc/uri/QmVkaSwgVXBhc2FuYQ==|https://frl.publisso.de/adhoc/uri/S2F6ZXJvdW5pLCBaYWhyYSBCLg==|https://orcid.org/0000-0003-2869-7762|https://orcid.org/0000-0003-1198-5805|https://orcid.org/0000-0003-0750-6998
1000 Hinweis
  • DeepGreen-ID: aea9a08a1e0941179837a8052c3d5ba3 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
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1000 @id frl:6443692.rdf
1000 Erstellt am 2023-04-27T10:23:09.627+0200
1000 Erstellt von 322
1000 beschreibt frl:6443692
1000 Zuletzt bearbeitet Thu Oct 19 15:24:44 CEST 2023
1000 Objekt bearb. Thu Oct 19 15:24:44 CEST 2023
1000 Vgl. frl:6443692
1000 Oai Id
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