Impact of prior JAK-inhibitor therapy with ruxolitinib on outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis: a study of the CMWP of EBMT

  1. Kröger, Nicolaus ORCID logo
  2. Sbianchi, Giulia
  3. Sirait, Tiarlan
  4. Wolschke, Christine
  5. Beelen, Dietrich
  6. Passweg, Jakob
  7. Robin, Marie ORCID logo
  8. Vrhovac, Radovan
  9. Helbig, Grzegorz
  10. Sockel, Katja ORCID logo
  11. Conneally, Eibhlin
  12. Rubio, Marie Thérèse
  13. Beguin, Yves
  14. Finke, Jürgen
  15. Bernasconi, Paolo
  16. Morozova, Elena
  17. Clausen, Johannes ORCID logo
  18. von dem Borne, Peter
  19. Schaap, Nicolaas
  20. Schroyens, Wilfried
  21. Patriarca, Francesca
  22. di renzo, nicola ORCID logo
  23. Yeğin, Zeynep Arzu
  24. Hayden, Patrick
  25. McLornan, Donal ORCID logo
  26. Yakoub-Agha, Ibrahim ORCID logo

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1000 Titel
  • Impact of prior JAK-inhibitor therapy with ruxolitinib on outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis: a study of the CMWP of EBMT
1000 Autor/in
  1. Kröger, Nicolaus |
  2. Sbianchi, Giulia |
  3. Sirait, Tiarlan |
  4. Wolschke, Christine |
  5. Beelen, Dietrich |
  6. Passweg, Jakob |
  7. Robin, Marie |
  8. Vrhovac, Radovan |
  9. Helbig, Grzegorz |
  10. Sockel, Katja |
  11. Conneally, Eibhlin |
  12. Rubio, Marie Thérèse |
  13. Beguin, Yves |
  14. Finke, Jürgen |
  15. Bernasconi, Paolo |
  16. Morozova, Elena |
  17. Clausen, Johannes |
  18. von dem Borne, Peter |
  19. Schaap, Nicolaas |
  20. Schroyens, Wilfried |
  21. Patriarca, Francesca |
  22. di renzo, nicola |
  23. Yeğin, Zeynep Arzu |
  24. Hayden, Patrick |
  25. McLornan, Donal |
  26. Yakoub-Agha, Ibrahim |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-05-22
1000 Erschienen in
1000 Quellenangabe
  • 35(12):3551-3560
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41375-021-01276-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632691/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment with RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated the impact of RUX on outcome in 551 myelofibrosis patients who received HSCT without (n = 274) or with (n = 277) RUX pretreatment. The overall leukocyte engraftment on day 45 was 92% and significantly higher in RUX responsive patients than those who had no or lost response to RUX (94% vs. 85%, p = 0.05). The 1-year non-relapse mortality was 22% without significant difference between the arms. In a multivariate analysis (MVA) RUX pretreated patients with ongoing spleen response at transplant had a significantly lower risk of relapse (8.1% vs. 19.1%; p = 0.04)] and better 2-year event-free survival (68.9% vs. 53.7%; p = 0.02) in comparison to patients without RUX pretreatment. For overall survival the only significant factors were age > 58 years (p = 0.03) and HLA mismatch donor (p = 0.001). RUX prior to HSCT did not negatively impact outcome after transplantation and patients with ongoing spleen response at time of transplantation had best outcome.
1000 Sacherschließung
lokal Female [MeSH]
lokal Nitriles/therapeutic use [MeSH]
lokal Aged [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Treatment Outcome [MeSH]
lokal Pyrazoles/therapeutic use [MeSH]
lokal Janus Kinase Inhibitors/therapeutic use [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Translational research
lokal Myeloproliferative disease
lokal Recurrence [MeSH]
lokal Survival Rate [MeSH]
lokal Primary Myelofibrosis/drug therapy [MeSH]
lokal Article
lokal Primary Myelofibrosis/therapy [MeSH]
lokal Pyrimidines/therapeutic use [MeSH]
lokal Male [MeSH]
lokal Graft vs Host Disease/immunology [MeSH]
lokal Primary Myelofibrosis/pathology [MeSH]
lokal Hematopoietic Stem Cell Transplantation/methods [MeSH]
lokal Graft vs Host Disease/pathology [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5103-9966|https://frl.publisso.de/adhoc/uri/U2JpYW5jaGksIEdpdWxpYQ==|https://frl.publisso.de/adhoc/uri/U2lyYWl0LCBUaWFybGFu|https://frl.publisso.de/adhoc/uri/V29sc2Noa2UsIENocmlzdGluZQ==|https://frl.publisso.de/adhoc/uri/QmVlbGVuLCBEaWV0cmljaA==|https://frl.publisso.de/adhoc/uri/UGFzc3dlZywgSmFrb2I=|https://orcid.org/0000-0003-1388-9876|https://frl.publisso.de/adhoc/uri/VnJob3ZhYywgUmFkb3Zhbg==|https://frl.publisso.de/adhoc/uri/SGVsYmlnLCBHcnplZ29yeg==|https://orcid.org/0000-0003-1732-7299|https://frl.publisso.de/adhoc/uri/Q29ubmVhbGx5LCBFaWJobGlu|https://frl.publisso.de/adhoc/uri/UnViaW8sIE1hcmllIFRow6lyw6hzZQ==|https://frl.publisso.de/adhoc/uri/QmVndWluLCBZdmVz|https://frl.publisso.de/adhoc/uri/Rmlua2UsIErDvHJnZW4=|https://frl.publisso.de/adhoc/uri/QmVybmFzY29uaSwgUGFvbG8=|https://frl.publisso.de/adhoc/uri/TW9yb3pvdmEsIEVsZW5h|https://orcid.org/0000-0002-2729-9706|https://frl.publisso.de/adhoc/uri/dm9uIGRlbSBCb3JuZSwgUGV0ZXI=|https://frl.publisso.de/adhoc/uri/U2NoYWFwLCBOaWNvbGFhcw==|https://frl.publisso.de/adhoc/uri/U2Nocm95ZW5zLCBXaWxmcmllZA==|https://frl.publisso.de/adhoc/uri/UGF0cmlhcmNhLCBGcmFuY2VzY2E=|https://orcid.org/0000-0003-0604-6934|https://frl.publisso.de/adhoc/uri/WWXEn2luLCBaZXluZXAgQXJ6dQ==|https://frl.publisso.de/adhoc/uri/SGF5ZGVuLCBQYXRyaWNr|https://orcid.org/0000-0003-1224-091X|https://orcid.org/0000-0003-4524-8782
1000 Hinweis
  • DeepGreen-ID: 0898dc62085848269f5402c8f72a3d8b ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-04-27T10:56:02.055+0200
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1000 Zuletzt bearbeitet 2023-10-20T09:50:04.535+0200
1000 Objekt bearb. Fri Oct 20 09:50:04 CEST 2023
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