CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

  1. Doehn, Jan-Moritz
  2. Tabeling, Christoph
  3. Biesen, Robert
  4. Saccomanno, Jacopo
  5. Madlung, Elena
  6. Pappe, Eva
  7. Gabriel, Frieder
  8. Kurth, Florian
  9. Meisel, Christian
  10. Corman, Victor M.
  11. Hanitsch, Leif G.
  12. Treskatsch, Sascha
  13. Heim, Kathrin
  14. Stegemann, Miriam S.
  15. Ruwwe-Glösenkamp, Christoph
  16. Müller-Redetzky, Holger C.
  17. Uhrig, Alexander
  18. Somasundaram, Rajan
  19. Spies, Claudia
  20. von Bernuth, Horst
  21. Hofmann, Jörg
  22. Drosten, Christian
  23. Suttorp, Norbert
  24. Witzenrath, Martin
  25. Sander, Leif E.
  26. Hübner, Ralf-Harto

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WeightNameValue
1000 Titel
  • CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
1000 Autor/in
  1. Doehn, Jan-Moritz |
  2. Tabeling, Christoph |
  3. Biesen, Robert |
  4. Saccomanno, Jacopo |
  5. Madlung, Elena |
  6. Pappe, Eva |
  7. Gabriel, Frieder |
  8. Kurth, Florian |
  9. Meisel, Christian |
  10. Corman, Victor M. |
  11. Hanitsch, Leif G. |
  12. Treskatsch, Sascha |
  13. Heim, Kathrin |
  14. Stegemann, Miriam S. |
  15. Ruwwe-Glösenkamp, Christoph |
  16. Müller-Redetzky, Holger C. |
  17. Uhrig, Alexander |
  18. Somasundaram, Rajan |
  19. Spies, Claudia |
  20. von Bernuth, Horst |
  21. Hofmann, Jörg |
  22. Drosten, Christian |
  23. Suttorp, Norbert |
  24. Witzenrath, Martin |
  25. Sander, Leif E. |
  26. Hübner, Ralf-Harto |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-06
1000 Erschienen in
1000 Quellenangabe
  • 49(4):757-762
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-021-01606-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023546/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
1000 Sacherschließung
lokal SARS-CoV-2/physiology [MeSH]
gnd 1206347392 COVID-19
lokal CD169
lokal Female [MeSH]
lokal COVID-19/immunology [MeSH]
lokal Aged [MeSH]
lokal Hospitalization [MeSH]
lokal Humans [MeSH]
lokal Severity of Illness Index [MeSH]
lokal Longitudinal Studies [MeSH]
lokal Monocytes/immunology [MeSH]
lokal Sialic Acid Binding Ig-like Lectin 1/blood [MeSH]
lokal Retrospective Studies [MeSH]
lokal Type I interferons
lokal Middle Aged [MeSH]
lokal Up-Regulation [MeSH]
lokal COVID-19
lokal COVID-19 / SARS-CoV-2
lokal Brief Report
lokal Male [MeSH]
lokal SARS-CoV-2
lokal SIGLEC1
lokal Sialic Acid Binding Ig-like Lectin 1/biosynthesis [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-04-27T11:50:13.524+0200
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1000 Zuletzt bearbeitet Fri Oct 20 11:55:28 CEST 2023
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