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1000 Titel
  • Targeting abundant survivin expression in liposarcoma: subtype dependent therapy responses to YM155 treatment
1000 Autor/in
  1. Vay, Christian |
  2. Schlünder, Philipp M. |
  3. Dizdar, Levent |
  4. Esposito, Irene |
  5. Ghadimi, Markus P. H. |
  6. Knoefel, Wolfram T. |
  7. Krieg, Andreas |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-03
1000 Erschienen in
1000 Quellenangabe
  • 148(3):633-645
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00432-021-03871-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881260/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Liposarcoma (LPS) represent the largest group of malignant soft tissue tumours comprising a heterogeneous group of subtypes in which the degrees of chemoresistance and radiosensitivity strongly vary. Consequently, it is of utmost interest to establish novel therapeutic regimens based on molecular targets.!##!Methods!#!Immunohistochemical staining of survivin was performed in tissue microarrays comprising 49 primary LPS specimens. LPS cell lines were treated with survivin antagonist YM155 and doxorubicin or etoposide alone as well as in combination. Changes in cell viability were investigated and the synergistic effect of a combined therapy analysed.!##!Results!#!Immunohistochemistry revealed an abundant expression of survivin in LPS that significantly concurred with less-differentiated tumour subtypes and grading. In vitro, we demonstrated the impact of the survivin inhibitor YM155 on dedifferentiated LPS (DDLPS) and, even more imposing, pleomorphic LPS (PLS) tumour cell viability with a strong induction of apoptosis. A combined treatment of doxorubicin or etoposide with YM155 augmented the cytotoxic effects on DDLPS and PLS cells.!##!Conclusion!#!These findings support the significant role of survivin in the oncogenesis and progression of LPS subtypes providing a rationale to target survivin in eligible in-vivo models and to pioneer clinical applications of survivin-specific substances unfolding their therapeutic potential in LPS patients prospectively.
1000 Sacherschließung
lokal Aged, 80 and over [MeSH]
lokal Liposarcoma
lokal Aged [MeSH]
lokal Survivin/antagonists
lokal Naphthoquinones/administration
lokal Tumor Cells, Cultured [MeSH]
lokal Etoposide/administration
lokal Male [MeSH]
lokal Doxorubicin/administration
lokal Targeted therapy
lokal Liposarcoma/drug therapy [MeSH]
lokal Liposarcoma/classification [MeSH]
lokal Liposarcoma/pathology [MeSH]
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Original Article – Cancer Research
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Apoptosis
lokal Middle Aged [MeSH]
lokal Survivin
lokal Gene Expression Regulation, Neoplastic/drug effects [MeSH]
lokal Survival Rate [MeSH]
lokal Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH]
lokal Prognosis [MeSH]
lokal Liposarcoma/metabolism [MeSH]
lokal Inhibitor of apoptosis protein
lokal Imidazoles/administration
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VmF5LCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/U2NobMO8bmRlciwgUGhpbGlwcCBNLg==|https://frl.publisso.de/adhoc/uri/RGl6ZGFyLCBMZXZlbnQ=|https://frl.publisso.de/adhoc/uri/RXNwb3NpdG8sIElyZW5l|https://frl.publisso.de/adhoc/uri/R2hhZGltaSwgTWFya3VzIFAuIEgu|https://frl.publisso.de/adhoc/uri/S25vZWZlbCwgV29sZnJhbSBULg==|https://orcid.org/0000-0003-2496-1079
1000 Hinweis
  • DeepGreen-ID: edea9b2b427944dfbfa43b276e36a011 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6446878.rdf
1000 Erstellt am 2023-04-28T14:27:21.692+0200
1000 Erstellt von 322
1000 beschreibt frl:6446878
1000 Zuletzt bearbeitet 2023-10-20T19:11:00.570+0200
1000 Objekt bearb. Fri Oct 20 19:11:00 CEST 2023
1000 Vgl. frl:6446878
1000 Oai Id
  1. oai:frl.publisso.de:frl:6446878 |
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