Impact of germline polymorphisms in genes regulating glucose uptake on positron emission tomography findings and outcome in diffuse large B-cell lymphoma: results from the PETAL trial

  1. Broecker-Preuss, Martina ORCID logo
  2. Becher-Boveleth, Nina
  3. Müller, Stefan P.
  4. Hüttmann, Andreas ORCID logo
  5. , Christine ORCID logo
  6. Grafe, Hong
  7. Richter, Julia ORCID logo
  8. Klapper, Wolfram ORCID logo
  9. Rekowski, Jan ORCID logo
  10. Bockisch, Andreas ORCID logo
  11. Dührsen, Ulrich ORCID logo

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1000 Titel
  • Impact of germline polymorphisms in genes regulating glucose uptake on positron emission tomography findings and outcome in diffuse large B-cell lymphoma: results from the PETAL trial
1000 Autor/in
  1. Broecker-Preuss, Martina |
  2. Becher-Boveleth, Nina |
  3. Müller, Stefan P. |
  4. Hüttmann, Andreas |
  5. , Christine |
  6. Grafe, Hong |
  7. Richter, Julia |
  8. Klapper, Wolfram |
  9. Rekowski, Jan |
  10. Bockisch, Andreas |
  11. Dührsen, Ulrich |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-27
1000 Erschienen in
1000 Quellenangabe
  • 148(10):2611-2621
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00432-021-03796-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470686/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#![!##!Methods!#!Clinical variables, FDG-PET findings, and outcome were analysed in relation to SNPs in 342 DLBCL patients participating in the 'Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas' (PETAL) trial. Genes analysed included SLC2A1 (SNPs rs1385129, referred to as HaeIII; rs710218, HpyCH4V; rs841853, XbaI), VEGFA (rs3025039), HIF1A (rs11549465, P582S; rs11549467, A588T), and APEX1 (rs1130409, D148E). Statistical significance was assumed at p ≤ 0.05.!##!Results!#!The SLC2A1 HaeIII and HpyCH4V SNPs were tightly linked and statistically significantly associated with baseline maximum standardized uptake value (SUV!##!Conclusions!#!Common SNPs in genes regulating glucose uptake may impact SUV!##!Trial registration!#!Trial registration: ClinicalTrials.gov NCT00554164; EudraCT 2006-001641-33. Registration date November 5, 2007, https://www.!##!Clinicaltrials!#!gov/ct2/show/NCT00554164.
1000 Sacherschließung
lokal Germ Cells/pathology [MeSH]
lokal Outcome
lokal Positron emission tomography
lokal Glucose metabolism
lokal Lymphoma, Large B-Cell, Diffuse/genetics [MeSH]
lokal Single nucleotide polymorphism
lokal Original Article – Clinical Oncology
lokal Humans [MeSH]
lokal Radiopharmaceuticals [MeSH]
lokal Diffuse large B-cell lymphoma
lokal Retrospective Studies [MeSH]
lokal Standardized uptake value
lokal Total metabolic tumour volume
lokal Fluorodeoxyglucose F18 [MeSH]
lokal Glucose [MeSH]
lokal Lymphoma, Large B-Cell, Diffuse/diagnostic imaging [MeSH]
lokal Positron-Emission Tomography/methods [MeSH]
lokal Prognosis [MeSH]
lokal Positron Emission Tomography Computed Tomography/methods [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4537-0964|https://frl.publisso.de/adhoc/uri/QmVjaGVyLUJvdmVsZXRoLCBOaW5h|https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgU3RlZmFuIFAu|https://orcid.org/0000-0003-2230-3873|https://orcid.org/0000-0003-2766-1696|https://frl.publisso.de/adhoc/uri/R3JhZmUsIEhvbmc=|https://orcid.org/0000-0002-9543-4084|https://orcid.org/0000-0001-7208-4117|https://orcid.org/0000-0002-5207-3864|https://orcid.org/0000-0001-5783-7862|https://orcid.org/0000-0002-4034-9472
1000 Hinweis
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1000 Erstellt am 2023-04-28T14:32:06.605+0200
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