Left ventricular depression and pulmonary edema in rats after short-term normobaric hypoxia: effects of adrenergic blockade and reduced fluid load

  1. Appelt, Peter
  2. Gabriel, Philipp
  3. Bölter, Christian
  4. Fiedler, Nicole
  5. Schierle, Katrin
  6. Salameh, Aida
  7. Raßler, Beate ORCID logo

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1000 Titel
  • Left ventricular depression and pulmonary edema in rats after short-term normobaric hypoxia: effects of adrenergic blockade and reduced fluid load
1000 Autor/in
  1. Appelt, Peter |
  2. Gabriel, Philipp |
  3. Bölter, Christian |
  4. Fiedler, Nicole |
  5. Schierle, Katrin |
  6. Salameh, Aida |
  7. Raßler, Beate |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-12
1000 Erschienen in
1000 Quellenangabe
  • 473(11):1723-1735
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00424-021-02618-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528748/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Acute normobaric hypoxia may induce pulmonary injury with edema (PE) and inflammation. Hypoxia is accompanied by sympathetic activation. As both acute hypoxia and high plasma catecholamine levels may elicit PE, we had originally expected that adrenergic blockade may attenuate the severity of hypoxic pulmonary injury. In particular, we investigated whether administration of drugs with reduced fluid load would be beneficial with respect to both cardiocirculatory and pulmonary functions in acute hypoxia. Rats were exposed to normobaric hypoxia (10% O
1000 Sacherschließung
lokal Adrenergic blockade
lokal Female [MeSH]
lokal Integrative Physiology
lokal Cardiac function
lokal Fluid load
lokal Heart Ventricles/physiopathology [MeSH]
lokal Inflammation
lokal Hypoxia/chemically induced [MeSH]
lokal Rats [MeSH]
lokal Rats, Sprague-Dawley [MeSH]
lokal Heart Ventricles/drug effects [MeSH]
lokal Animals [MeSH]
lokal Lung/drug effects [MeSH]
lokal Lung/physiopathology [MeSH]
lokal Adrenergic Antagonists/pharmacology [MeSH]
lokal Hypoxia/physiopathology [MeSH]
lokal Pulmonary edema
lokal Pulmonary Edema/physiopathology [MeSH]
lokal Normobaric hypoxia
lokal Pulmonary Edema/chemically induced [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QXBwZWx0LCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/R2FicmllbCwgUGhpbGlwcA==|https://frl.publisso.de/adhoc/uri/QsO2bHRlciwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/RmllZGxlciwgTmljb2xl|https://frl.publisso.de/adhoc/uri/U2NoaWVybGUsIEthdHJpbg==|https://frl.publisso.de/adhoc/uri/U2FsYW1laCwgQWlkYQ==|https://orcid.org/0000-0003-3526-2388
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1000 Erstellt am 2023-04-28T14:34:49.265+0200
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