The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

  1. Seidel, Christoph ORCID logo
  2. Daugaard, Gedske
  3. Nestler, Tim
  4. Tryakin, Alexey
  5. Fedyanin, Mikhail
  6. Fankhauser, Christian Daniel
  7. Hermanns, Thomas
  8. Aparicio, Jorge
  9. Heinzelbecker, Julia
  10. Paffenholz, Pia
  11. Heidenreich, Axel
  12. De Giorgi, Ugo
  13. Cathomas, Richard
  14. Lorch, Anja
  15. Fingerhut, Anna
  16. Gayer, Fabian
  17. Bremmer, Felix
  18. Giannatempo, Patrizia
  19. Necchi, Andrea
  20. Raggi, Daniele
  21. Aurilio, Gaetano
  22. Casadei, Chiara
  23. Hentrich, Marcus
  24. Tran, Ben
  25. Dieckmann, Klaus-Peter
  26. Brito, Margarido
  27. Ruf, Christian
  28. Mazzocca, Alessandro
  29. Vincenzi, Bruno
  30. Stahl, Olof
  31. Bokemeyer, Carsten
  32. Oing, Christoph

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1000 Titel
  • The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)
1000 Autor/in
  1. Seidel, Christoph |
  2. Daugaard, Gedske |
  3. Nestler, Tim |
  4. Tryakin, Alexey |
  5. Fedyanin, Mikhail |
  6. Fankhauser, Christian Daniel |
  7. Hermanns, Thomas |
  8. Aparicio, Jorge |
  9. Heinzelbecker, Julia |
  10. Paffenholz, Pia |
  11. Heidenreich, Axel |
  12. De Giorgi, Ugo |
  13. Cathomas, Richard |
  14. Lorch, Anja |
  15. Fingerhut, Anna |
  16. Gayer, Fabian |
  17. Bremmer, Felix |
  18. Giannatempo, Patrizia |
  19. Necchi, Andrea |
  20. Raggi, Daniele |
  21. Aurilio, Gaetano |
  22. Casadei, Chiara |
  23. Hentrich, Marcus |
  24. Tran, Ben |
  25. Dieckmann, Klaus-Peter |
  26. Brito, Margarido |
  27. Ruf, Christian |
  28. Mazzocca, Alessandro |
  29. Vincenzi, Bruno |
  30. Stahl, Olof |
  31. Bokemeyer, Carsten |
  32. Oing, Christoph |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-08
1000 Erschienen in
1000 Quellenangabe
  • 39(9):3407-3414
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00345-021-03635-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510898/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and other clinical characteristics in this subset of patients.!##!Methods!#!Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR).!##!Results!#!The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-off LDH level of < 2.5 upper limit of normal (ULN) (n = 228) vs. ≥ 2.5 ULN (n = 123) to be associated with a significant difference concerning OS associated with 5-years OS rates of 93% vs. 83% (p = 0.001) which was confirmed in multivariate analysis (HR 2.87; p = 0.004). Furthermore, the cut-off LDH < 2.5 ULN vs. ≥ 2.5 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76% vs. 86% (p = 0.012) and 32% vs. 59% (p  ≤  0.001), respectively.!##!Conclusions!#!LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification.
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Lactate dehydrogenase
lokal Seminoma
lokal Aged [MeSH]
lokal Prognostic markers
lokal Adult [MeSH]
lokal Testicular Neoplasms/mortality [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Upper limit of normal
lokal Original Article
lokal L-Lactate Dehydrogenase/blood [MeSH]
lokal Neoplasm Staging [MeSH]
lokal Survival Rate [MeSH]
lokal Male [MeSH]
lokal Seminoma/mortality [MeSH]
lokal Prognosis [MeSH]
lokal Testicular Neoplasms/blood [MeSH]
lokal Young Adult [MeSH]
lokal Seminoma/pathology [MeSH]
lokal Testicular Neoplasms/pathology [MeSH]
lokal Seminoma/blood [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6023-6336|https://frl.publisso.de/adhoc/uri/RGF1Z2FhcmQsIEdlZHNrZQ==|https://frl.publisso.de/adhoc/uri/TmVzdGxlciwgVGlt|https://frl.publisso.de/adhoc/uri/VHJ5YWtpbiwgQWxleGV5|https://frl.publisso.de/adhoc/uri/RmVkeWFuaW4sIE1pa2hhaWw=|https://frl.publisso.de/adhoc/uri/RmFua2hhdXNlciwgQ2hyaXN0aWFuIERhbmllbA==|https://frl.publisso.de/adhoc/uri/SGVybWFubnMsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/QXBhcmljaW8sIEpvcmdl|https://frl.publisso.de/adhoc/uri/SGVpbnplbGJlY2tlciwgSnVsaWE=|https://frl.publisso.de/adhoc/uri/UGFmZmVuaG9seiwgUGlh|https://frl.publisso.de/adhoc/uri/SGVpZGVucmVpY2gsIEF4ZWw=|https://frl.publisso.de/adhoc/uri/RGUgR2lvcmdpLCBVZ28=|https://frl.publisso.de/adhoc/uri/Q2F0aG9tYXMsIFJpY2hhcmQ=|https://frl.publisso.de/adhoc/uri/TG9yY2gsIEFuamE=|https://frl.publisso.de/adhoc/uri/RmluZ2VyaHV0LCBBbm5h|https://frl.publisso.de/adhoc/uri/R2F5ZXIsIEZhYmlhbg==|https://frl.publisso.de/adhoc/uri/QnJlbW1lciwgRmVsaXg=|https://frl.publisso.de/adhoc/uri/R2lhbm5hdGVtcG8sIFBhdHJpemlh|https://frl.publisso.de/adhoc/uri/TmVjY2hpLCBBbmRyZWE=|https://frl.publisso.de/adhoc/uri/UmFnZ2ksIERhbmllbGU=|https://frl.publisso.de/adhoc/uri/QXVyaWxpbywgR2FldGFubw==|https://frl.publisso.de/adhoc/uri/Q2FzYWRlaSwgQ2hpYXJh|https://frl.publisso.de/adhoc/uri/SGVudHJpY2gsIE1hcmN1cw==|https://frl.publisso.de/adhoc/uri/VHJhbiwgQmVu|https://frl.publisso.de/adhoc/uri/RGllY2ttYW5uLCBLbGF1cy1QZXRlcg==|https://frl.publisso.de/adhoc/uri/QnJpdG8sIE1hcmdhcmlkbw==|https://frl.publisso.de/adhoc/uri/UnVmLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/TWF6em9jY2EsIEFsZXNzYW5kcm8=|https://frl.publisso.de/adhoc/uri/VmluY2VuemksIEJydW5v|https://frl.publisso.de/adhoc/uri/U3RhaGwsIE9sb2Y=|https://frl.publisso.de/adhoc/uri/Qm9rZW1leWVyLCBDYXJzdGVu|https://frl.publisso.de/adhoc/uri/T2luZywgQ2hyaXN0b3Bo
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1000 Erstellt am 2023-05-03T16:16:44.147+0200
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