Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q)

  1. Hecht, Anna
  2. Meyer, Julia A.
  3. Jann, Johann-Christoph
  4. Sockel, Katja
  5. Giagounidis, Aristoteles
  6. Götze, Katharina S.
  7. Letsch, Anne
  8. Haase, Detlef
  9. Schlenk, Richard F.
  10. Haferlach, Torsten
  11. Schafhausen, Philippe
  12. Bug, Gesine
  13. Lübbert, Michael
  14. Thol, Felicitas
  15. Büsche, Guntram
  16. Schuler, Esther
  17. Nowak, Verena
  18. Obländer, Julia
  19. Fey, Stephanie
  20. Müller, Nadine
  21. Metzgeroth, Georgia
  22. Hofmann, Wolf-Karsten
  23. Germing, Ulrich
  24. Nolte, Florian
  25. Reinwald, Mark
  26. Nowak, Daniel

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WeightNameValue
1000 Titel
  • Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q)
1000 Autor/in
  1. Hecht, Anna |
  2. Meyer, Julia A. |
  3. Jann, Johann-Christoph |
  4. Sockel, Katja |
  5. Giagounidis, Aristoteles |
  6. Götze, Katharina S. |
  7. Letsch, Anne |
  8. Haase, Detlef |
  9. Schlenk, Richard F. |
  10. Haferlach, Torsten |
  11. Schafhausen, Philippe |
  12. Bug, Gesine |
  13. Lübbert, Michael |
  14. Thol, Felicitas |
  15. Büsche, Guntram |
  16. Schuler, Esther |
  17. Nowak, Verena |
  18. Obländer, Julia |
  19. Fey, Stephanie |
  20. Müller, Nadine |
  21. Metzgeroth, Georgia |
  22. Hofmann, Wolf-Karsten |
  23. Germing, Ulrich |
  24. Nolte, Florian |
  25. Reinwald, Mark |
  26. Nowak, Daniel |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-27
1000 Erschienen in
1000 Quellenangabe
  • 100(6):1463-1471
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00277-021-04492-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116243/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Myelodysplastic syndrome (MDS) with isolated deletion of chromosome 5q (MDS del5q) is a distinct subtype of MDS with quite favorable prognosis and excellent response to treatment with lenalidomide. Still, a relevant percentage of patients do not respond to lenalidomide and even experience progression to acute myeloid leukemia (AML). In this study, we aimed to investigate whether global DNA methylation patterns could predict response to lenalidomide. Genome-wide DNA methylation analysis using Illumina 450k methylation arrays was performed on n=51 patients with MDS del5q who were uniformly treated with lenalidomide in a prospective multicenter trial of the German MDS study group. To study potential direct effects of lenalidomide on DNA methylation, 17 paired samples pre- and post-treatment were analyzed. Our results revealed no relevant effect of lenalidomide on methylation status. Furthermore, methylation patterns prior to therapy could not predict lenalidomide response. However, methylation clustering identified a group of patients with a trend towards inferior overall survival. These patients showed hypermethylation of several interesting target genes, including genes of relevant signaling pathways, potentially indicating the evaluation of novel therapeutic targets.
1000 Sacherschließung
lokal Myelodysplastic syndromes
lokal Deletion 5q
lokal Female [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Chromosomes, Human, Pair 5/genetics [MeSH]
lokal Aged [MeSH]
lokal DNA Methylation/drug effects [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Lenalidomide
lokal Treatment Outcome [MeSH]
lokal Antineoplastic Agents/pharmacology [MeSH]
lokal Middle Aged [MeSH]
lokal Myelodysplastic Syndromes/genetics [MeSH]
lokal Original Article
lokal Male [MeSH]
lokal Myelodysplastic Syndromes/drug therapy [MeSH]
lokal Antineoplastic Agents/therapeutic use [MeSH]
lokal Chromosome Deletion [MeSH]
lokal DNA methylation
lokal Lenalidomide/pharmacology [MeSH]
lokal Lenalidomide/therapeutic use [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-05-03T16:34:13.054+0200
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1000 Zuletzt bearbeitet 2023-10-20T21:24:02.806+0200
1000 Objekt bearb. Fri Oct 20 21:24:02 CEST 2023
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