Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors —results of the Heinz Nixdorf Recall Study

  1. Pechlivanis, Sonali
  2. Jung, Dominik ORCID logo
  3. Moebus, Susanne
  4. Lehmann, Nils
  5. Mahabadi, Amir A.
  6. Hoffmann, Per
  7. Erbel, Raimund
  8. Nöthen, Markus M.
  9. Bachmann, Hagen ORCID logo

Download
s00210-021-02100-7.pdf 936,92KB
WeightNameValue
1000 Titel
  • Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors —results of the Heinz Nixdorf Recall Study
1000 Autor/in
  1. Pechlivanis, Sonali |
  2. Jung, Dominik |
  3. Moebus, Susanne |
  4. Lehmann, Nils |
  5. Mahabadi, Amir A. |
  6. Hoffmann, Per |
  7. Erbel, Raimund |
  8. Nöthen, Markus M. |
  9. Bachmann, Hagen |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-05-22
1000 Erschienen in
1000 Quellenangabe
  • 394(8):1713-1725
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00210-021-02100-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298241/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, including those with diabetes mellitus (DM). However, intake of HMGRIs also increases the progression of coronary artery calcification (CAC) and the risk of developing DM. This study aimed to investigate whether HMGRI intake interacts with the diabetes-associated genetic risk score (GRS) to affect CAC progression using data from the population-based Heinz Nixdorf Recall (HNR) study. CAC was measured in 3157 participants using electron-beam computed tomography twice, at baseline (CAC
1000 Sacherschließung
lokal Diabetes Mellitus, Type 2/epidemiology [MeSH]
lokal Coronary Artery Disease/pathology [MeSH]
lokal Disease Progression [MeSH]
lokal Cohort study
lokal Aged [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Vascular Calcification/pathology [MeSH]
lokal HMG-CoA-reductase inhibitors
lokal Risk Factors [MeSH]
lokal Original Article
lokal Progression of coronary artery calcification
lokal Tomography, X-Ray Computed [MeSH]
lokal Male [MeSH]
lokal Diabetes Mellitus, Type 2/genetics [MeSH]
lokal Genetic risk score
lokal Genetic Predisposition to Disease [MeSH]
lokal Female [MeSH]
lokal Diabetes mellitus
lokal Humans [MeSH]
lokal Coronary Artery Disease/drug therapy [MeSH]
lokal Middle Aged [MeSH]
lokal Vascular Calcification/drug therapy [MeSH]
lokal Pleiotropic effects
lokal Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology [MeSH]
lokal Pharmacogenetics [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGVjaGxpdmFuaXMsIFNvbmFsaQ==|https://orcid.org/0000-0003-4288-6455|https://frl.publisso.de/adhoc/uri/TW9lYnVzLCBTdXNhbm5l|https://frl.publisso.de/adhoc/uri/TGVobWFubiwgTmlscw==|https://frl.publisso.de/adhoc/uri/TWFoYWJhZGksIEFtaXIgQS4=|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFBlcg==|https://frl.publisso.de/adhoc/uri/RXJiZWwsIFJhaW11bmQ=|https://frl.publisso.de/adhoc/uri/TsO2dGhlbiwgTWFya3VzIE0u|https://orcid.org/0000-0002-8642-540X
1000 Hinweis
  • DeepGreen-ID: 8cfef044038b4f9690878bd4c6867614 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6448001.rdf
1000 Erstellt am 2023-05-03T17:05:05.615+0200
1000 Erstellt von 322
1000 beschreibt frl:6448001
1000 Zuletzt bearbeitet Fri Oct 20 21:44:34 CEST 2023
1000 Objekt bearb. Fri Oct 20 21:44:34 CEST 2023
1000 Vgl. frl:6448001
1000 Oai Id
  1. oai:frl.publisso.de:frl:6448001 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source