Evolution of the ancestral mammalian karyotype and syntenic regions

  1. Damas, Joana ORCID logo
  2. Corbo, Marco
  3. Kim, Jaebum
  4. Turner-Maier, Jason
  5. Farré, Marta
  6. Larkin, Denis M.
  7. Ryder, Oliver ORCID logo
  8. Steiner, Cynthia
  9. Houck, Marlys L.
  10. Hall, Shaune
  11. Shiue, Lily
  12. Thomas, Stephen
  13. Swale, Thomas
  14. Daly, Mark
  15. Korlach, Jonas
  16. Uliano-Silva, Marcela
  17. Mazzoni, Camila J.
  18. Birren, Bruce W.
  19. Genereux, Diane ORCID logo
  20. Johnson, Jeremy
  21. Lindblad-Toh, Kerstin ORCID logo
  22. Karlsson, Elinor ORCID logo
  23. Nweeia, Martin ORCID logo
  24. Johnson, Rebecca ORCID logo
  25. Lewin, Harris ORCID logo

Download
pnas.2209139119.pdf 2,19MB
WeightNameValue
1000 Titel
  • Evolution of the ancestral mammalian karyotype and syntenic regions
1000 Autor/in
  1. Damas, Joana |
  2. Corbo, Marco |
  3. Kim, Jaebum |
  4. Turner-Maier, Jason |
  5. Farré, Marta |
  6. Larkin, Denis M. |
  7. Ryder, Oliver |
  8. Steiner, Cynthia |
  9. Houck, Marlys L. |
  10. Hall, Shaune |
  11. Shiue, Lily |
  12. Thomas, Stephen |
  13. Swale, Thomas |
  14. Daly, Mark |
  15. Korlach, Jonas |
  16. Uliano-Silva, Marcela |
  17. Mazzoni, Camila J. |
  18. Birren, Bruce W. |
  19. Genereux, Diane |
  20. Johnson, Jeremy |
  21. Lindblad-Toh, Kerstin |
  22. Karlsson, Elinor |
  23. Nweeia, Martin |
  24. Johnson, Rebecca |
  25. Lewin, Harris |
1000 Mitwirkende/r
  1. Zoonomia Consortium |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-09-26
1000 Erschienen in
1000 Quellenangabe
  • 119(40):e2209139119
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1073/pnas.2209139119 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550189/ |
1000 Ergänzendes Material
  • https://www.pnas.org/doi/full/10.1073/pnas.2209139119#supplementary-materials |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Decrypting the rearrangements that drive mammalian chromosome evolution is critical to understanding the molecular bases of speciation, adaptation, and disease susceptibility. Using 8 scaffolded and 26 chromosome-scale genome assemblies representing 23/26 mammal orders, we computationally reconstructed ancestral karyotypes and syntenic relationships at 16 nodes along the mammalian phylogeny. Three different reference genomes (human, sloth, and cattle) representing phylogenetically distinct mammalian superorders were used to assess reference bias in the reconstructed ancestral karyotypes and to expand the number of clades with reconstructed genomes. The mammalian ancestor likely had 19 pairs of autosomes, with nine of the smallest chromosomes shared with the common ancestor of all amniotes (three still conserved in extant mammals), demonstrating a striking conservation of synteny for ∼320 My of vertebrate evolution. The numbers and types of chromosome rearrangements were classified for transitions between the ancestral mammalian karyotype, descendent ancestors, and extant species. For example, 94 inversions, 16 fissions, and 14 fusions that occurred over 53 My differentiated the therian from the descendent eutherian ancestor. The highest breakpoint rate was observed between the mammalian and therian ancestors (3.9 breakpoints/My). Reconstructed mammalian ancestor chromosomes were found to have distinct evolutionary histories reflected in their rates and types of rearrangements. The distributions of genes, repetitive elements, topologically associating domains, and actively transcribed regions in multispecies homologous synteny blocks and evolutionary breakpoint regions indicate that purifying selection acted over millions of years of vertebrate evolution to maintain syntenic relationships of developmentally important genes and regulatory landscapes of gene-dense chromosomes.
1000 Sacherschließung
lokal Chromosomes, Mammalian/genetics [MeSH]
lokal Sloths/genetics [MeSH]
lokal Multidisciplinary
lokal Humans [MeSH]
lokal Evolution, Molecular [MeSH]
lokal Synteny/genetics [MeSH]
lokal Animals [MeSH]
lokal Mammals/genetics [MeSH]
lokal Phylogeny [MeSH]
lokal Karyotype [MeSH]
lokal Cattle/genetics [MeSH]
lokal Eutheria/genetics [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4857-2510|https://frl.publisso.de/adhoc/uri/Q29yYm8sIE1hcmNv|https://frl.publisso.de/adhoc/uri/S2ltLCBKYWVidW0=|https://frl.publisso.de/adhoc/uri/VHVybmVyLU1haWVyLCBKYXNvbg==|https://frl.publisso.de/adhoc/uri/RmFycsOpLCBNYXJ0YQ==|https://frl.publisso.de/adhoc/uri/TGFya2luLCBEZW5pcyBNLg==|https://orcid.org/0000-0003-2427-763X|https://frl.publisso.de/adhoc/uri/U3RlaW5lciwgQ3ludGhpYQ==|https://frl.publisso.de/adhoc/uri/SG91Y2ssIE1hcmx5cyBMLg==|https://frl.publisso.de/adhoc/uri/SGFsbCwgU2hhdW5l|https://frl.publisso.de/adhoc/uri/U2hpdWUsIExpbHk=|https://frl.publisso.de/adhoc/uri/VGhvbWFzLCBTdGVwaGVu|https://frl.publisso.de/adhoc/uri/U3dhbGUsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/RGFseSwgTWFyaw==|https://frl.publisso.de/adhoc/uri/S29ybGFjaCwgSm9uYXM=|https://frl.publisso.de/adhoc/uri/VWxpYW5vLVNpbHZhLCBNYXJjZWxh|https://frl.publisso.de/adhoc/uri/TWF6em9uaSwgQ2FtaWxhIEou|https://frl.publisso.de/adhoc/uri/QmlycmVuLCBCcnVjZSBXLg==|https://orcid.org/0000-0001-5770-0989|https://frl.publisso.de/adhoc/uri/Sm9obnNvbiwgSmVyZW15|https://orcid.org/0000-0001-8338-0253|https://orcid.org/0000-0002-4343-3776|https://orcid.org/0000-0001-7079-4123|https://orcid.org/0000-0003-3035-2827|https://orcid.org/0000-0002-1043-7287|https://frl.publisso.de/adhoc/uri/Wm9vbm9taWEgQ29uc29ydGl1bQ==
1000 Label
1000 Förderer
  1. Vetenskapsrådet |
  2. Robert and Rosabel Osborne Endowment |
  3. National Institute of Food and Agriculture |
1000 Fördernummer
  1. -
  2. -
  3. CA-D-EVE-2423-H
1000 Förderprogramm
  1. Distinguished Professorship
  2. -
  3. -
1000 Dateien
  1. Evolution of the ancestral mammalian karyotype and syntenic regions
    Evolution of the ancestral mammalian karyotype and syntenic regions
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Vetenskapsrådet |
    1000 Förderprogramm Distinguished Professorship
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Robert and Rosabel Osborne Endowment |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer National Institute of Food and Agriculture |
    1000 Förderprogramm -
    1000 Fördernummer CA-D-EVE-2423-H
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6449468.rdf
1000 Erstellt am 2023-05-05T09:16:26.441+0200
1000 Erstellt von 336
1000 beschreibt frl:6449468
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2023-05-17T08:49:41.873+0200
1000 Objekt bearb. Wed May 17 08:48:18 CEST 2023
1000 Vgl. frl:6449468
1000 Oai Id
  1. oai:frl.publisso.de:frl:6449468 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source