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1000 Titel
  • Cystatin C relates to metabolism in healthy, pubertal adolescents
1000 Autor/in
  1. Ziegelasch, Niels |
  2. Vogel, Mandy |
  3. Körner, Antje |
  4. Koch, Eva |
  5. Jurkutat, Anne |
  6. Ceglarek, Uta |
  7. Dittrich, Katalin |
  8. Kiess, Wieland |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-25
1000 Erschienen in
1000 Quellenangabe
  • 37(2):423-432
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00467-021-05209-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816513/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Introduction!#!The cystatin C (CysC) serum level is a marker of glomerular filtration rate and depends on age, gender, and pubertal stage. We hypothesize that CysC might overall reflect energy homeostasis and be regulated by components of the endocrine system and metabolites in pubertal adolescents.!##!Methods!#!Serum CysC levels and further possible effector parameters in 5355 fasting, morning venous blood samples from 2035 healthy participants of the LIFE Child cohort study (age 8 to 18 years) were analyzed. Recruitment started in 2011, with probands followed up once a year. Linear univariate and stepwise multivariate regression analyses were performed.!##!Results!#!Annual growth rate, serum levels of thyroid hormones, parathyroid hormone, insulin-like growth factor 1, hemoglobin A1c (HbA1c), uric acid, and alkaline phosphatase show relevant and significant associations with CysC serum concentrations (p <0.001). Furthermore, male probands' CysC correlated with the body mass index and testosterone among other sexual hormones. Multivariate analyses revealed that uric acid and HbA1c are associated variables of CysC independent from gender (p <0.001). In males, alkaline phosphatase (p <0.001) is additionally significantly associated with CysC. Thyroid hormones show significant correlations only in multivariate analyses in females (p <0.001).!##!Conclusions!#!The described associations strongly suggest an impact of children's metabolism on CysC serum levels. These alterations need to be considered in kidney diagnostics using CysC in adolescents. Additionally, further studies are needed on CysC in children.
1000 Sacherschließung
lokal Alkaline Phosphatase [MeSH]
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Hormone
lokal Enzyme
lokal Humans [MeSH]
lokal Uric Acid [MeSH]
lokal Cystatin C/blood [MeSH]
lokal Cohort Studies [MeSH]
lokal Original Article
lokal Glomerular Filtration Rate [MeSH]
lokal Male [MeSH]
lokal Children
lokal Creatinine [MeSH]
lokal Cystatin C
lokal Biomarkers [MeSH]
lokal Metabolism
lokal Child [MeSH]
lokal Glycated Hemoglobin A [MeSH]
lokal Puberty
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-2656-0965|https://frl.publisso.de/adhoc/uri/Vm9nZWwsIE1hbmR5|https://frl.publisso.de/adhoc/uri/S8O2cm5lciwgQW50amU=|https://frl.publisso.de/adhoc/uri/S29jaCwgRXZh|https://frl.publisso.de/adhoc/uri/SnVya3V0YXQsIEFubmU=|https://frl.publisso.de/adhoc/uri/Q2VnbGFyZWssIFV0YQ==|https://frl.publisso.de/adhoc/uri/RGl0dHJpY2gsIEthdGFsaW4=|https://frl.publisso.de/adhoc/uri/S2llc3MsIFdpZWxhbmQ=
1000 Hinweis
  • DeepGreen-ID: a6f07539766648b38b452472be03e2d6 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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  1. Cystatin C relates to metabolism in healthy, pubertal adolescents
1000 Objektart article
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1000 @id frl:6449736.rdf
1000 Erstellt am 2023-05-09T09:58:43.874+0200
1000 Erstellt von 322
1000 beschreibt frl:6449736
1000 Zuletzt bearbeitet 2023-10-21T01:27:53.566+0200
1000 Objekt bearb. Sat Oct 21 01:27:53 CEST 2023
1000 Vgl. frl:6449736
1000 Oai Id
  1. oai:frl.publisso.de:frl:6449736 |
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