Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19

  1. Geis, Tobias
  2. Brandstetter, Susanne
  3. Toncheva, Antoaneta A.
  4. Wagner, Ralf
  5. Kabesch, Michael
  6. Kasser, Severin
  7. Kuhle, Jens
  8. Wellmann, Sven ORCID logo
  9. Aichholzer, Bettina
  10. Mair, Georg
  11. Wruk, Michaela
  12. Reischl, Imke
  13. Ambrosch, Andreas
  14. Antos, David
  15. von Koskull, Stephan
  16. Becker, Christian
  17. Beer, Elisabeth
  18. Schirmer, Hubert
  19. Birkinger, Georg
  20. Blueml, Andreas
  21. Buntrock-Döpke, Heike
  22. Castrop, Mona
  23. Dieckerhoff, Jost
  24. Eichhorn, Renate
  25. Ewald, Dominik
  26. Heihoff, Gudrun Fleck Alfred
  27. Geuder, Jürgen
  28. Grombach, Jens
  29. Gutdeutsch, Peter
  30. Segerer, Florian
  31. Habash, Thomas
  32. Habash, Sonja
  33. Harner, Susanne
  34. Herbst, Christoph
  35. Heuschmann, Daniela
  36. Hofmann, Meike
  37. Horn, Michael
  38. Jork-Kaeferlein, Birgit
  39. Schwarz, Monika
  40. Hopfner, Reinhard
  41. Judex, Guido
  42. Baumgartner, Bastian
  43. Corbacioglu, Monika
  44. Lindner, Sabrina
  45. Meinel, Bettina
  46. Bauer, Alena
  47. Löw, Hannes
  48. Szulagyi-Kovacs, Annamaria
  49. Laub, Sarah
  50. Klein, Annegret
  51. Koering, Cosima
  52. Landvogt, Niclas
  53. Soehngen, Claudia
  54. Rasp, Karin
  55. Schick-Niedermeier, Gudrun
  56. Laub, Marinus
  57. Laub, Otto
  58. Leipold, Georg
  59. Schmid-Seibold, Petra
  60. Pawlak, Johannes
  61. Reitz, Michaela
  62. Puchner, Georg
  63. Peterhoff, David
  64. Razeghi, Christiane
  65. Razeghi, Stefan
  66. Rehe, Christine
  67. Rehe, Klaus
  68. Scheffel, Matthias
  69. Kaesbauer, Ludwig
  70. Schmid, Roland
  71. Strobelt, Michael
  72. Schoetzau, Nina
  73. Schweiger-Kabesch, Andrea
  74. Senjor, Marko
  75. Sperlich, Michael
  76. Theuerer, Guenter
  77. Steidle, Guenter
  78. Tretter, German
  79. von Arnim, Victor
  80. Volz-Fleckenstein, Marlene
  81. Einhauser, Sebastian
  82. Neckermann, Patrick
  83. Borchers, Natascha
  84. Santos-Valente, Elisangela
  85. Kheiroddin, Parastoo
  86. Schöberl, Patricia
  87. Niggel, Jakob
  88. Gerling, Stephan

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WeightNameValue
1000 Titel
  • Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19
1000 Autor/in
  1. Geis, Tobias |
  2. Brandstetter, Susanne |
  3. Toncheva, Antoaneta A. |
  4. Wagner, Ralf |
  5. Kabesch, Michael |
  6. Kasser, Severin |
  7. Kuhle, Jens |
  8. Wellmann, Sven |
  9. Aichholzer, Bettina |
  10. Mair, Georg |
  11. Wruk, Michaela |
  12. Reischl, Imke |
  13. Ambrosch, Andreas |
  14. Antos, David |
  15. von Koskull, Stephan |
  16. Becker, Christian |
  17. Beer, Elisabeth |
  18. Schirmer, Hubert |
  19. Birkinger, Georg |
  20. Blueml, Andreas |
  21. Buntrock-Döpke, Heike |
  22. Castrop, Mona |
  23. Dieckerhoff, Jost |
  24. Eichhorn, Renate |
  25. Ewald, Dominik |
  26. Heihoff, Gudrun Fleck Alfred |
  27. Geuder, Jürgen |
  28. Grombach, Jens |
  29. Gutdeutsch, Peter |
  30. Segerer, Florian |
  31. Habash, Thomas |
  32. Habash, Sonja |
  33. Harner, Susanne |
  34. Herbst, Christoph |
  35. Heuschmann, Daniela |
  36. Hofmann, Meike |
  37. Horn, Michael |
  38. Jork-Kaeferlein, Birgit |
  39. Schwarz, Monika |
  40. Hopfner, Reinhard |
  41. Judex, Guido |
  42. Baumgartner, Bastian |
  43. Corbacioglu, Monika |
  44. Lindner, Sabrina |
  45. Meinel, Bettina |
  46. Bauer, Alena |
  47. Löw, Hannes |
  48. Szulagyi-Kovacs, Annamaria |
  49. Laub, Sarah |
  50. Klein, Annegret |
  51. Koering, Cosima |
  52. Landvogt, Niclas |
  53. Soehngen, Claudia |
  54. Rasp, Karin |
  55. Schick-Niedermeier, Gudrun |
  56. Laub, Marinus |
  57. Laub, Otto |
  58. Leipold, Georg |
  59. Schmid-Seibold, Petra |
  60. Pawlak, Johannes |
  61. Reitz, Michaela |
  62. Puchner, Georg |
  63. Peterhoff, David |
  64. Razeghi, Christiane |
  65. Razeghi, Stefan |
  66. Rehe, Christine |
  67. Rehe, Klaus |
  68. Scheffel, Matthias |
  69. Kaesbauer, Ludwig |
  70. Schmid, Roland |
  71. Strobelt, Michael |
  72. Schoetzau, Nina |
  73. Schweiger-Kabesch, Andrea |
  74. Senjor, Marko |
  75. Sperlich, Michael |
  76. Theuerer, Guenter |
  77. Steidle, Guenter |
  78. Tretter, German |
  79. von Arnim, Victor |
  80. Volz-Fleckenstein, Marlene |
  81. Einhauser, Sebastian |
  82. Neckermann, Patrick |
  83. Borchers, Natascha |
  84. Santos-Valente, Elisangela |
  85. Kheiroddin, Parastoo |
  86. Schöberl, Patricia |
  87. Niggel, Jakob |
  88. Gerling, Stephan |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-23
1000 Erschienen in
1000 Quellenangabe
  • 268(11):3969-3974
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-021-10554-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064423/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Serum neurofilament light chain (sNfL) is an established biomarker of neuro-axonal damage in multiple neurological disorders. Raised sNfL levels have been reported in adults infected with pandemic coronavirus disease 2019 (COVID-19). Levels in children infected with COVID-19 have not as yet been reported.!##!Objective!#!To evaluate whether sNfL is elevated in children contracting COVID-19.!##!Methods!#!Between May 22 and July 22, 2020, a network of outpatient pediatricians in Bavaria, Germany, the Coronavirus antibody screening in children from Bavaria study network (CoKiBa), recruited healthy children into a cross-sectional study from two sources: an ongoing prevention program for 1-14 years, and referrals of 1-17 years consulting a pediatrician for possible infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We determined sNfL levels by single molecule array immunoassay and SARS-CoV-2 antibody status by two independent quantitative methods.!##!Results!#!Of the 2652 included children, 148 (5.6%) were SARS-CoV-2 antibody positive with asymptomatic to moderate COVID-19 infection. Neurological symptoms-headache, dizziness, muscle aches, or loss of smell and taste-were present in 47/148 cases (31.8%). Mean sNfL levels were 5.5 pg/ml (SD 2.9) in the total cohort, 5.1 (SD 2.1) pg/ml in the children with SARS-CoV-2 antibodies, and 5.5 (SD 3.0) pg/ml in those without. Multivariate regression analysis revealed age-but neither antibody status, antibody levels, nor clinical severity-as an independent predictor of sNfL. Follow-up of children with pediatric multisystem inflammatory syndrome (n = 14) showed no association with sNfL.!##!Conclusions!#!In this population study, children with asymptomatic to moderate COVID-19 showed no neurochemical evidence of neuronal damage.
1000 Sacherschließung
lokal Neurology
gnd 1206347392 COVID-19
lokal Brain
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Neurofilament Proteins [MeSH]
lokal COVID-19
lokal Cross-Sectional Studies [MeSH]
lokal Systemic Inflammatory Response Syndrome [MeSH]
lokal Children
lokal COVID-19 [MeSH]
lokal Original Communication
lokal Child [MeSH]
lokal SARS-CoV-2 [MeSH]
lokal Intermediate Filaments [MeSH]
lokal Neurofilament
1000 Liste der Beteiligten
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