Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning

  1. Hirschhäuser, Christine
  2. Lissoni, Alessio
  3. Görge, Philipp Maximilian
  4. Lampe, Paul D.
  5. Heger, Jacqueline
  6. Schlüter, Klaus-Dieter
  7. Leybaert, Luc
  8. Schulz, Rainer
  9. Boengler, Kerstin

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WeightNameValue
1000 Titel
  • Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning
1000 Autor/in
  1. Hirschhäuser, Christine |
  2. Lissoni, Alessio |
  3. Görge, Philipp Maximilian |
  4. Lampe, Paul D. |
  5. Heger, Jacqueline |
  6. Schlüter, Klaus-Dieter |
  7. Leybaert, Luc |
  8. Schulz, Rainer |
  9. Boengler, Kerstin |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-22
1000 Erschienen in
1000 Quellenangabe
  • 116(1):21
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-021-00861-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985055/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Myocardial connexin 43 (Cx43) forms gap junctions and hemichannels, and is also present within subsarcolemmal mitochondria. The protein is phosphorylated by several kinases including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and casein kinase 1 (CK1). A reduction in Cx43 content abrogates myocardial infarct size reduction by ischemic preconditioning (IPC). The present study characterizes the contribution of Cx43 phosphorylation towards mitochondrial function, hemichannel activity, and the cardioprotection by IPC in wild-type (WT) mice and in mice in which Cx43-phosphorylation sites targeted by above kinases are mutated to non-phosphorylatable residues (Cx43
1000 Sacherschließung
lokal Mitochondria
lokal Connexin
lokal Phosphorylation [MeSH]
lokal Original Contribution
lokal Myocardial Infarction/pathology [MeSH]
lokal Mitochondria, Heart/enzymology [MeSH]
lokal Myocardial Reperfusion Injury/genetics [MeSH]
lokal Ischemic preconditioning
lokal Ischemia/reperfusion
lokal Phosphorylation
lokal Myocardial Infarction/enzymology [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Hemichannel
lokal Myocardial Reperfusion Injury/pathology [MeSH]
lokal Mitochondria, Heart/pathology [MeSH]
lokal Myocardial Infarction/prevention
lokal Myocytes, Cardiac/enzymology [MeSH]
lokal Casein Kinase I/metabolism [MeSH]
lokal Myocardial Infarction/genetics [MeSH]
lokal Animals [MeSH]
lokal Ischemic Preconditioning, Myocardial [MeSH]
lokal Myocytes, Cardiac/pathology [MeSH]
lokal Mitochondria, Heart/genetics [MeSH]
lokal Myocardial Reperfusion Injury/prevention
lokal Mice, Mutant Strains [MeSH]
lokal Myocardial Reperfusion Injury/enzymology [MeSH]
lokal Connexin 43/genetics [MeSH]
lokal Connexin 43/metabolism [MeSH]
lokal Isolated Heart Preparation [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SGlyc2NoaMOkdXNlciwgQ2hyaXN0aW5l|https://frl.publisso.de/adhoc/uri/TGlzc29uaSwgQWxlc3Npbw==|https://frl.publisso.de/adhoc/uri/R8O2cmdlLCBQaGlsaXBwIE1heGltaWxpYW4=|https://frl.publisso.de/adhoc/uri/TGFtcGUsIFBhdWwgRC4=|https://frl.publisso.de/adhoc/uri/SGVnZXIsIEphY3F1ZWxpbmU=|https://frl.publisso.de/adhoc/uri/U2NobMO8dGVyLCBLbGF1cy1EaWV0ZXI=|https://frl.publisso.de/adhoc/uri/TGV5YmFlcnQsIEx1Yw==|https://frl.publisso.de/adhoc/uri/U2NodWx6LCBSYWluZXI=|https://frl.publisso.de/adhoc/uri/Qm9lbmdsZXIsIEtlcnN0aW4=
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1000 Erstellt am 2023-05-11T10:56:42.056+0200
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1000 Zuletzt bearbeitet Sat Oct 21 04:00:28 CEST 2023
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