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1000 Titel
  • Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study
1000 Autor/in
  1. ahn, nayeon |
  2. Frenzel, Stefan |
  3. Wittfeld, Katharina |
  4. Bülow, Robin |
  5. Völzke, Henry |
  6. Lerch, Markus M. |
  7. Chenot, Jean-Francois |
  8. Schminke, Ulf |
  9. Nolde, Michael |
  10. Amann, Ute |
  11. Meisinger, Christa |
  12. Linseisen, Jakob |
  13. Baumeister, Sebastian E. |
  14. Grabe, Hans Jörgen |
  15. Rückert-Eheberg, Ina-Maria |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-13
1000 Erschienen in
1000 Quellenangabe
  • 77(7):1039-1048
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00228-020-03068-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184524/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.!##!Methods!#!Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use.!##!Results!#!No association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95% confidence interval: - 2.06 to - 0.16) in immediate recall, and 0.72 lower (95% CI: - 1.22 to - 0.22) in delayed recall in PPI users than in non-users. PPI use was unrelated to the NAI score.!##!Conclusions!#!The present study does not support a relationship between PPI use and brain aging.
1000 Sacherschließung
lokal Cognition/drug effects [MeSH]
lokal Dementia
lokal Female [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Proton Pump Inhibitors/adverse effects [MeSH]
lokal Adult [MeSH]
lokal Brain/drug effects [MeSH]
lokal Humans [MeSH]
lokal Brain volume
lokal Middle Aged [MeSH]
lokal Cross-Sectional Studies [MeSH]
lokal Proton Pump Inhibitors/administration
lokal Male [MeSH]
lokal Germany [MeSH]
lokal Young Adult [MeSH]
lokal Magnetic resonance imaging
lokal Cognitive impairment
lokal Proton pump inhibitors
lokal Pharmacoepidemiology and Prescription
lokal Aging/drug effects [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4414-114X|https://frl.publisso.de/adhoc/uri/RnJlbnplbCwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/V2l0dGZlbGQsIEthdGhhcmluYQ==|https://frl.publisso.de/adhoc/uri/QsO8bG93LCBSb2Jpbg==|https://frl.publisso.de/adhoc/uri/VsO2bHprZSwgSGVucnk=|https://frl.publisso.de/adhoc/uri/TGVyY2gsIE1hcmt1cyBNLg==|https://frl.publisso.de/adhoc/uri/Q2hlbm90LCBKZWFuLUZyYW5jb2lz|https://frl.publisso.de/adhoc/uri/U2NobWlua2UsIFVsZg==|https://frl.publisso.de/adhoc/uri/Tm9sZGUsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/QW1hbm4sIFV0ZQ==|https://frl.publisso.de/adhoc/uri/TWVpc2luZ2VyLCBDaHJpc3Rh|https://frl.publisso.de/adhoc/uri/TGluc2Vpc2VuLCBKYWtvYg==|https://frl.publisso.de/adhoc/uri/QmF1bWVpc3RlciwgU2ViYXN0aWFuIEUu|https://frl.publisso.de/adhoc/uri/R3JhYmUsIEhhbnMgSsO2cmdlbg==|https://frl.publisso.de/adhoc/uri/UsO8Y2tlcnQtRWhlYmVyZywgSW5hLU1hcmlh
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1000 Erstellt am 2023-05-11T14:05:02.591+0200
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