Post-VX exposure treatment of rats with engineered phosphotriesterases

  1. Stigler, Lisa
  2. Köhler, Anja
  3. Koller, Marianne
  4. Job, Laura
  5. Escher, Benjamin
  6. Potschka, Heidrun
  7. Thiermann, Horst
  8. Skerra, Arne
  9. Worek, Franz
  10. Wille, Timo ORCID logo

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WeightNameValue
1000 Titel
  • Post-VX exposure treatment of rats with engineered phosphotriesterases
1000 Autor/in
  1. Stigler, Lisa |
  2. Köhler, Anja |
  3. Koller, Marianne |
  4. Job, Laura |
  5. Escher, Benjamin |
  6. Potschka, Heidrun |
  7. Thiermann, Horst |
  8. Skerra, Arne |
  9. Worek, Franz |
  10. Wille, Timo |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-28
1000 Erschienen in
1000 Quellenangabe
  • 96(2):571-583
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-03199-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837561/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient. Recently, two engineered mutants of the Brevundimonas diminuta phosphotriesterase (PTE) with enhanced catalytic efficiency (k
1000 Sacherschließung
lokal Acetylcholinesterase
lokal Detoxification
lokal Chemical Warfare Agents/toxicity [MeSH]
lokal Protein Engineering [MeSH]
lokal Stereoisomerism [MeSH]
lokal Caulobacteraceae/enzymology [MeSH]
lokal Molecular Toxicology
lokal In vivo
lokal Therapy
lokal Rats [MeSH]
lokal Catalytic bioscavenger
lokal Animals [MeSH]
lokal PASylation
lokal Rats, Wistar [MeSH]
lokal Phosphotriesterase
lokal Male [MeSH]
lokal Cholinesterase Inhibitors/toxicity [MeSH]
lokal Phosphoric Triester Hydrolases/chemistry [MeSH]
lokal Organothiophosphorus Compounds/toxicity [MeSH]
lokal Organophosphate
lokal Phosphoric Triester Hydrolases/pharmacology [MeSH]
lokal Phosphoric Triester Hydrolases/genetics [MeSH]
lokal Enzyme engineering
lokal VX
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U3RpZ2xlciwgTGlzYQ==|https://frl.publisso.de/adhoc/uri/S8O2aGxlciwgQW5qYQ==|https://frl.publisso.de/adhoc/uri/S29sbGVyLCBNYXJpYW5uZQ==|https://frl.publisso.de/adhoc/uri/Sm9iLCBMYXVyYQ==|https://frl.publisso.de/adhoc/uri/RXNjaGVyLCBCZW5qYW1pbg==|https://frl.publisso.de/adhoc/uri/UG90c2Noa2EsIEhlaWRydW4=|https://frl.publisso.de/adhoc/uri/VGhpZXJtYW5uLCBIb3JzdA==|https://frl.publisso.de/adhoc/uri/U2tlcnJhLCBBcm5l|https://frl.publisso.de/adhoc/uri/V29yZWssIEZyYW56|https://orcid.org/0000-0002-4359-5388
1000 Hinweis
  • DeepGreen-ID: 42874989d0f24b2fa6c86b779cdbec71 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
  1. Post-VX exposure treatment of rats with engineered phosphotriesterases
    Post-VX exposure treatment of rats with engineered phosphotriesterases
1000 Objektart article
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1000 @id frl:6451627.rdf
1000 Erstellt am 2023-05-11T14:13:24.971+0200
1000 Erstellt von 322
1000 beschreibt frl:6451627
1000 Zuletzt bearbeitet Tue Oct 24 08:07:56 CEST 2023
1000 Objekt bearb. Tue Oct 24 08:07:56 CEST 2023
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6451627 |
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