Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells

  1. Müller, Lena
  2. Schütte, Larissa Rhonda Friederike
  3. Bücksteeg, David
  4. Alfke, Julian
  5. Uebel, Thomas
  6. Esselen, Melanie ORCID logo

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WeightNameValue
1000 Titel
  • Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells
1000 Autor/in
  1. Müller, Lena |
  2. Schütte, Larissa Rhonda Friederike |
  3. Bücksteeg, David |
  4. Alfke, Julian |
  5. Uebel, Thomas |
  6. Esselen, Melanie |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-12
1000 Erschienen in
1000 Quellenangabe
  • 95(12):3787-3802
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-03162-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536574/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Nevadensin, an abundant polyphenol of basil, is reported to reduce alkenylbenzene DNA adduct formation. Furthermore, it has a wide spectrum of further pharmacological properties. The presented study focuses the impact of nevadensin on topoisomerases (TOPO) in vitro. Considering the DNA-intercalating properties of flavonoids, first, minor groove binding properties (IC
1000 Sacherschließung
lokal Dose-Response Relationship, Drug [MeSH]
lokal Poly-ADP-Ribose Binding Proteins/drug effects [MeSH]
lokal Humans [MeSH]
lokal Apoptosis/drug effects [MeSH]
lokal Plant polyphenol
lokal HT29 Cells [MeSH]
lokal Genotoxicity and Carcinogenicity
lokal DNA Topoisomerases, Type I/drug effects [MeSH]
lokal Topoisomerase I
lokal Time Factors [MeSH]
lokal DNA Damage/drug effects [MeSH]
lokal Flavone
lokal Cell Cycle/drug effects [MeSH]
lokal DNA Topoisomerases, Type II/drug effects [MeSH]
lokal Flavones/poisoning [MeSH]
lokal Caspase activity
lokal Cell cycle arrest
lokal Inhibitory Concentration 50 [MeSH]
lokal Colonic Neoplasms/enzymology [MeSH]
lokal Flavones/administration
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgTGVuYQ==|https://frl.publisso.de/adhoc/uri/U2Now7x0dGUsIExhcmlzc2EgUmhvbmRhIEZyaWVkZXJpa2U=|https://frl.publisso.de/adhoc/uri/QsO8Y2tzdGVlZywgRGF2aWQ=|https://frl.publisso.de/adhoc/uri/QWxma2UsIEp1bGlhbg==|https://frl.publisso.de/adhoc/uri/VWViZWwsIFRob21hcw==|https://orcid.org/0000-0002-7590-6179
1000 Hinweis
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1000 Dateien
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1000 Erstellt am 2023-05-11T14:15:41.428+0200
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1000 Zuletzt bearbeitet Tue Oct 24 08:30:27 CEST 2023
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