A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure

  1. Verma, Nisha ORCID logo
  2. Pink, Mario
  3. Schmitz-Spanke, Simone

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1000 Titel
  • A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure
1000 Autor/in
  1. Verma, Nisha |
  2. Pink, Mario |
  3. Schmitz-Spanke, Simone |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-27
1000 Erschienen in
1000 Quellenangabe
  • 95(6):2007-2018
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-03032-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166691/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Toxicological studies propose that exposure to carbon black nanoparticles induces organ injuries and inflammatory responses. Besides, current understanding of the molecular mechanisms implies that carbon black nanoparticles (CBNP) exposure induces the production of reactive oxygen species (ROS) causing inflammation, mitochondrial dysfunction or disturbance in calcium homeostasis. However, the precise mechanisms whereby CBNP exert these effects in the lung are still not fully understood. To gain insight into the possible mechanism of CBNP exerted toxicity, human alveolar epithelial cells (A549) were exposed to different concentrations of CBNP and for different timepoints. The reaction of the cells was monitored by the systematic use of cell-based measurements of calcium and ROS, in the presence and absence of calcium (Ca
1000 Sacherschließung
lokal A549 Cells [MeSH]
lokal Dose-Response Relationship, Drug [MeSH]
lokal Calcium/metabolism [MeSH]
lokal Antioxidants/pharmacology [MeSH]
lokal Reactive oxygen species (ROS)
lokal Calmodulin/metabolism [MeSH]
lokal Oxidative Stress/genetics [MeSH]
lokal Nanoparticles/toxicity [MeSH]
lokal Humans [MeSH]
lokal Mitochondrial ROS
lokal Reactive Oxygen Species/metabolism [MeSH]
lokal Alveolar Epithelial Cells/pathology [MeSH]
lokal Time Factors [MeSH]
lokal Alveolar Epithelial Cells/drug effects [MeSH]
lokal Nanotoxicology
lokal Carbon black nanoparticles
lokal Soot/administration
lokal Gene Expression Regulation/drug effects [MeSH]
lokal Oxidative Stress/drug effects [MeSH]
lokal Soot/toxicity [MeSH]
lokal Calcium homeostasis
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7558-167X|https://frl.publisso.de/adhoc/uri/UGluaywgTWFyaW8=|https://frl.publisso.de/adhoc/uri/U2NobWl0ei1TcGFua2UsIFNpbW9uZQ==
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1000 Erstellt am 2023-05-11T14:29:20.819+0200
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1000 Zuletzt bearbeitet Mon Oct 23 15:51:45 CEST 2023
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