Download
mb0cbphpcbe6016.pdf 176,33KB
WeightNameValue
1000 Titel
  • Chlorinated biphenyls : MAK Value Documentation, 2016
1000 Titelzusatz
  • MAK Value Documentations – Chlorinated biphenyls
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2016
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-10-26
1000 Erschienen in
1000 Quellenangabe
  • 1(4):2421-2441
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb0cbphpcbe6016 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of chlorinated biphenyls (PCB), considering all toxicological endpoints. Available publications are described in detail. The Commission re‐evaluated the previous distinction of PCB in two groups: congeners with up to 3 and 4 or more chlorine atoms. Recent inhalation studies show that the lung is not expected to be the primary target organ of PCB 3 and PCB 11 but the liver. In feeding studies, Aroclor mixtures containing congeners with up to 3 chlorine atoms yield only liver adenomas but no carcinomas in rats, although some of these congeners are genotoxic. On the other hand, Aroclor mixtures with high amounts of congeners with 4 and more chlorine atoms lead to a high incidence of liver carcinomas in rats. Therefore, for congeners with up to 3 chlorine atoms, the genotoxicity is not decisive for the development of liver tumours but mainly the tumour promotion, which has also been shown for congeners with 4 and more chlorine atoms. The distinction between these two groups is therefore no longer retained and all PCBs are classified in Carcinogen Category 4. As a 4‐week inhalation study in rats with a PCB containing mainly congeners with up to 3 chlorine atoms does not give rise to toxicity at a concentration which is 35 times higher than the previous MAK value for congeners with 4 and more chlorine atoms, this MAK value of 0.003 mg/m3 is now set for all PCBs. The assignment to Peak Limitation Category II with an excursion factor of 8 is retained due to the critical systemic effects and to the long half‐life of all PCB. The assignment to Pregnancy Risk Group B is retained, as all PCB damage to the embryo or foetus cannot be ruled out even when the MAK value is observed. The genotoxic potency in vivo is regarded as very low if the MAK value is observed, and all PCB are grouped into Germ Cell Mutagen Category 5.
1000 Sacherschließung
lokal Aroclor 1242
lokal chlorinated biphenyls
lokal MAK value
lokal PCB 3
lokal polychlorinated biphenyls
lokal metabolism
lokal developmental toxicity
lokal hazardous substance
lokal peak limitation
lokal (sub)chronic toxicity
lokal toxicity
lokal carcinogenicity
lokal 53469-21-9
lokal toxicokinetics
lokal Aroclor 1254
lokal PCB 11
lokal reproductive toxicity
lokal mechanism of action
lokal (sub)acute toxicity
lokal MAK Value Documentations
lokal germ cell mutagenicity
lokal maximum workplace concentration
lokal genotoxicity
lokal occupational exposure
lokal MAK-Begründungen
lokal prenatal toxicity
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006456377 |
1000 Liste der Beteiligten
  1. SGFydHdpZywgQW5kcmVh|TUFLIENvbW1pc3Npb24=
1000 Label
1000 Dateien
  1. Chlorinated biphenyls : MAK Value Documentation, 2016
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6456377.rdf
1000 Erstellt am 2023-08-25T07:35:49.253+0200
1000 Erstellt von 335
1000 beschreibt frl:6456377
1000 Zuletzt bearbeitet 2023-11-29T19:30:41.376+0100
1000 Objekt bearb. Wed Nov 29 19:30:41 CET 2023
1000 Vgl. frl:6456377
1000 Oai Id
  1. oai:frl.publisso.de:frl:6456377 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source