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1000 Titel
  • Isopropyl benzene (Cumene) : MAK Value Documentation, 2018
1000 Titelzusatz
  • MAK Value Documentations – Isopropyl benzene (Cumene)
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-10-19
1000 Erschienen in
1000 Quellenangabe
  • 3(4):1909-1917
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb9882e6418 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for isopropyl benzene [98‐82‐8]. Critical effects after repeated inhalation exposure to isopropyl benzene are the induction of tumours in the lung of mice and in the nose of rats as well as effects on the liver in these species. The classification of isopropyl benzene in Category 3 B for carcinogenic substances is retained. Based on the increased liver weight in a 14‐week inhalation study with rats, a MAK value of 10 ml/m3 has been set. This value is now reaffirmed even considering the increased respiratory volume at the workplace (see List of MAK and BAT Values, Sections I b and I c). As there was a change in the Commissions evaluation on the adversity of increased liver weight, the new evaluation is based on the lower confidence limit of the benchmark dose (BMDL) of 42 ml/m3 for nasal adenoma in male rats in a two‐year inhalation study. As there is no new data, Peak Limitation Category II with excursion factor of 4 is retained and isopropyl benzene remains assigned to Pregnancy Risk Group C. Isopropyl benzene also remains designated with an “H” (for substances that can be absorbed through the skin in toxicologically relevant amounts).
1000 Sacherschließung
lokal 2-phenylpropane
lokal toxicokinetics
lokal absorption through the skin
lokal MAK value
lokal cumol
lokal (sub)acute toxicity
lokal MAK Value Documentations
lokal germ cell mutagenicity
lokal maximum workplace concentration
lokal metabolism
lokal genotoxicity
lokal hazardous substance
lokal occupational exposure
lokal peak limitation
lokal MAK-Begründungen
lokal cumene
lokal prenatal toxicity
lokal (sub)chronic toxicity
lokal isopropyl benzene
lokal (1-methylethyl)benzene
lokal toxicity
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006461702 |
1000 Liste der Beteiligten
  1. SGFydHdpZywgQW5kcmVh|TUFLIENvbW1pc3Npb24=
1000 Label
1000 Dateien
  1. Isopropyl benzene (Cumene) : MAK Value Documentation, 2018
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6461702.rdf
1000 Erstellt am 2023-08-31T13:20:45.669+0200
1000 Erstellt von 335
1000 beschreibt frl:6461702
1000 Zuletzt bearbeitet 2023-11-30T03:01:38.959+0100
1000 Objekt bearb. Thu Nov 30 03:01:38 CET 2023
1000 Vgl. frl:6461702
1000 Oai Id
  1. oai:frl.publisso.de:frl:6461702 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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