Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor

  1. Carstensen, Saskia
  2. Gress, Christina
  3. Erpenbeck, Veit J.
  4. Kazani, Shamsah D.
  5. Hohlfeld, Jens M.
  6. Sandham, David A.
  7. Müller, Meike ORCID logo

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1000 Titel
  • Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor
1000 Autor/in
  1. Carstensen, Saskia |
  2. Gress, Christina |
  3. Erpenbeck, Veit J. |
  4. Kazani, Shamsah D. |
  5. Hohlfeld, Jens M. |
  6. Sandham, David A. |
  7. Müller, Meike |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-07
1000 Erschienen in
1000 Quellenangabe
  • 22(1):262
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12931-021-01852-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8499518/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Prostaglandin D!##!Methods!#!Eosinophils and ILC2s were isolated from peripheral blood of atopic asthmatic patients. Eosinophil shape change, ILC2 migration and IL-5/IL-13 cytokine secretion were measured after stimulation with seven PGD!##!Results!#!Selected metabolites induced eosinophil shape change with similar nanomolar potencies except for 9α,11β-PGF!##!Conclusion!#!Prostaglandin D
1000 Sacherschließung
lokal Lymphocytes/metabolism [MeSH]
lokal DP
lokal PGD
lokal Prostaglandin Antagonists/pharmacology [MeSH]
lokal Aged [MeSH]
lokal Indoleacetic Acids/pharmacology [MeSH]
lokal CRTH2
lokal Eosinophils/metabolism [MeSH]
lokal Type 2 innate lymphocyte cells
lokal Cell Movement/drug effects [MeSH]
lokal Lymphocytes/drug effects [MeSH]
lokal Male [MeSH]
lokal Receptors, Prostaglandin/agonists [MeSH]
lokal Lymphocytes/immunology [MeSH]
lokal Interleukin-5/metabolism [MeSH]
lokal 13,14-Dihydro-15-keto-PGD
lokal Eosinophils/drug effects [MeSH]
lokal Receptors, Immunologic/metabolism [MeSH]
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Pyridines/pharmacology [MeSH]
lokal Adult [MeSH]
lokal Asthma/immunology [MeSH]
lokal Eosinophil shape change
lokal Prostaglandin D2/analogs
lokal Humans [MeSH]
lokal Eosinophils/immunology [MeSH]
lokal Asthma
lokal Middle Aged [MeSH]
lokal Asthma/metabolism [MeSH]
lokal Fevipiprant
lokal Interleukin-13/metabolism [MeSH]
lokal Prostaglandin D2/pharmacology [MeSH]
lokal Research
lokal Young Adult [MeSH]
lokal Signal Transduction [MeSH]
lokal Receptors, Prostaglandin/metabolism [MeSH]
lokal Cell Shape/drug effects [MeSH]
lokal Cells, Cultured [MeSH]
lokal Asthma/drug therapy [MeSH]
lokal Receptors, Immunologic/agonists [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Q2Fyc3RlbnNlbiwgU2Fza2lh|https://frl.publisso.de/adhoc/uri/R3Jlc3MsIENocmlzdGluYQ==|https://frl.publisso.de/adhoc/uri/RXJwZW5iZWNrLCBWZWl0IEou|https://frl.publisso.de/adhoc/uri/S2F6YW5pLCBTaGFtc2FoIEQu|https://frl.publisso.de/adhoc/uri/SG9obGZlbGQsIEplbnMgTS4=|https://frl.publisso.de/adhoc/uri/U2FuZGhhbSwgRGF2aWQgQS4=|https://orcid.org/0000-0002-7586-356X
1000 Hinweis
  • DeepGreen-ID: 702a590fc0b54d61be5348effe64244f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-15T17:47:59.087+0100
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1000 Zuletzt bearbeitet 2023-11-30T21:24:00.423+0100
1000 Objekt bearb. Thu Nov 30 21:24:00 CET 2023
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