Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury

  1. patschan, daniel ORCID logo
  2. Schwarze, Katrin
  3. Tampe, Björn
  4. Becker, Jan Ulrich
  5. Hakroush, Samy
  6. Ritter, Oliver
  7. Patschan, Susann
  8. Müller, Gerhard Anton

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WeightNameValue
1000 Titel
  • Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury
1000 Autor/in
  1. patschan, daniel |
  2. Schwarze, Katrin |
  3. Tampe, Björn |
  4. Becker, Jan Ulrich |
  5. Hakroush, Samy |
  6. Ritter, Oliver |
  7. Patschan, Susann |
  8. Müller, Gerhard Anton |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-23
1000 Erschienen in
1000 Quellenangabe
  • 21(1):503
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12882-020-02149-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684746/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Endothelial Progenitor Cells have been shown as effective tool in experimental AKI. Several pharmacological strategies for improving EPC-mediated AKI protection were identified in recent years. Aim of the current study was to analyze consequences of constitutive Atg5 activation in murine EPCs, utilized for AKI therapy.!##!Methods!#!Ischemic AKI was induced in male C57/Bl6N mice. Cultured murine EPCs were systemically injected post-ischemia, either natively or after Atg5 transfection (Adenovirus-based approach). Mice were analyzed 48 h and 6 weeks later.!##!Results!#!Both, native and transfected EPCs (EPCs!##!Conclusions!#!Constitutive Atg5 activation augments AKI-protective effects of murine EPCs. The exact clinical consequences need to be determined.
1000 Sacherschließung
lokal Acute Kidney Injury/therapy [MeSH]
lokal Endothelial Progenitor Cells/metabolism [MeSH]
lokal Atg5
lokal Mice, Inbred C57BL [MeSH]
lokal Autophagy
lokal Kidney/metabolism [MeSH]
lokal Acute Kidney Injury/metabolism [MeSH]
lokal Hypertension, Hemodynamics and Vascular Regulation
lokal Animals [MeSH]
lokal EPCs
lokal Mice [MeSH]
lokal AKI
lokal Male [MeSH]
lokal Autophagy [MeSH]
lokal Endothelial Progenitor Cells/transplantation [MeSH]
lokal Kidney/pathology [MeSH]
lokal Cell- and Tissue-Based Therapy [MeSH]
lokal Research Article
lokal Autophagy-Related Protein 5/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6914-5254|https://frl.publisso.de/adhoc/uri/U2Nod2FyemUsIEthdHJpbg==|https://frl.publisso.de/adhoc/uri/VGFtcGUsIEJqw7Zybg==|https://frl.publisso.de/adhoc/uri/QmVja2VyLCBKYW4gVWxyaWNo|https://frl.publisso.de/adhoc/uri/SGFrcm91c2gsIFNhbXk=|https://frl.publisso.de/adhoc/uri/Uml0dGVyLCBPbGl2ZXI=|https://frl.publisso.de/adhoc/uri/UGF0c2NoYW4sIFN1c2Fubg==|https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgR2VyaGFyZCBBbnRvbg==
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1000 Erstellt am 2023-11-16T05:06:14.239+0100
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