Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease

  1. Lenders, Malte ORCID logo
  2. Brand, Eva

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1000 Titel
  • Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease
1000 Autor/in
  1. Lenders, Malte |
  2. Brand, Eva |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-08
1000 Erschienen in
1000 Quellenangabe
  • 81(17):1969-1981
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40265-021-01621-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602155/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (AGAL/GLA) gene. The lysosomal accumulation of the substrates globotriaosylceramide (Gb
1000 Sacherschließung
lokal Pharmacology/Toxicology
lokal Fabry Disease/physiopathology [MeSH]
lokal alpha-Galactosidase/adverse effects [MeSH]
lokal Enzyme Replacement Therapy/adverse effects [MeSH]
lokal Humans [MeSH]
lokal alpha-Galactosidase/therapeutic use [MeSH]
lokal Enzyme Replacement Therapy/methods [MeSH]
lokal Review Article
lokal Trihexosylceramides/metabolism [MeSH]
lokal Isoenzymes/adverse effects [MeSH]
lokal Risk Factors [MeSH]
lokal Lysosomal Storage Diseases/pathology [MeSH]
lokal Injection Site Reaction [MeSH]
lokal Recombinant Proteins/adverse effects [MeSH]
lokal Recombinant Proteins/therapeutic use [MeSH]
lokal Antibodies, Neutralizing/immunology [MeSH]
lokal Antibody Formation [MeSH]
lokal Male [MeSH]
lokal Fabry Disease/drug therapy [MeSH]
lokal Isoenzymes/therapeutic use [MeSH]
lokal Internal Medicine
lokal Pharmacotherapy
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8409-2886|https://frl.publisso.de/adhoc/uri/QnJhbmQsIEV2YQ==
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1000 Erstellt am 2023-11-16T09:54:11.275+0100
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