CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

  1. Sievers, Philipp
  2. Hielscher, Thomas
  3. Schrimpf, Daniel
  4. Stichel, Damian
  5. Reuss, David E.
  6. Berghoff, Anna S.
  7. Neidert, Marian C.
  8. Wirsching, Hans-Georg
  9. Mawrin, Christian
  10. Ketter, Ralf
  11. Paulus, Werner
  12. Reifenberger, Guido
  13. Lamszus, Katrin
  14. Westphal, Manfred
  15. Etminan, Nima
  16. Ratliff, Miriam
  17. Herold-Mende, Christel
  18. Pfister, Stefan M.
  19. Jones, David T. W.
  20. Weller, Michael
  21. Harter, Patrick N.
  22. Wick, Wolfgang
  23. Preusser, Matthias
  24. von Deimling, Andreas
  25. Sahm, Felix ORCID logo

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1000 Titel
  • CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas
1000 Autor/in
  1. Sievers, Philipp |
  2. Hielscher, Thomas |
  3. Schrimpf, Daniel |
  4. Stichel, Damian |
  5. Reuss, David E. |
  6. Berghoff, Anna S. |
  7. Neidert, Marian C. |
  8. Wirsching, Hans-Georg |
  9. Mawrin, Christian |
  10. Ketter, Ralf |
  11. Paulus, Werner |
  12. Reifenberger, Guido |
  13. Lamszus, Katrin |
  14. Westphal, Manfred |
  15. Etminan, Nima |
  16. Ratliff, Miriam |
  17. Herold-Mende, Christel |
  18. Pfister, Stefan M. |
  19. Jones, David T. W. |
  20. Weller, Michael |
  21. Harter, Patrick N. |
  22. Wick, Wolfgang |
  23. Preusser, Matthias |
  24. von Deimling, Andreas |
  25. Sahm, Felix |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-08
1000 Erschienen in
1000 Quellenangabe
  • 140(3):409-413
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00401-020-02188-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423850/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved treatment and reperfusion strategies, the uncompensated cardiomyocyte loss during injury and disease results in cardiac remodeling and subsequent heart failure. The promising field of regenerative medicine aims to restore both the structure and function of damaged tissue through modulation of cellular processes and regulatory mechanisms involved in cardiac cell cycle arrest to boost cardiomyocyte proliferation. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are functional RNA molecules with no protein-coding function that have been reported to engage in cardiac regeneration and repair. In this review, we summarize the current understanding of both the biological functions and molecular mechanisms of ncRNAs involved in cardiomyocyte proliferation. Furthermore, we discuss their impact on the structure and contractile function of the heart in health and disease and their application for therapeutic interventions.
1000 Sacherschließung
lokal Gene Deletion [MeSH]
lokal Homozygote [MeSH]
lokal Genes, p16/physiology [MeSH]
lokal Meningeal Neoplasms/genetics [MeSH]
lokal Humans [MeSH]
lokal Sequence Deletion/genetics [MeSH]
lokal Pathology
lokal Meningioma/genetics [MeSH]
lokal Neurosciences
lokal Cyclin-Dependent Kinase Inhibitor p16/genetics [MeSH]
lokal Correspondence
1000 Liste der Beteiligten
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