Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia

  1. Schieck, Maximilian ORCID logo
  2. Lentes, Jana
  3. Thomay, Kathrin
  4. Hofmann, Winfried
  5. Behrens, Yvonne Lisa
  6. Hagedorn, Maike
  7. Ebersold, Juliane
  8. Davenport, Colin F.
  9. Fazio, Grazia
  10. Möricke, Anja
  11. Buchmann, Swantje
  12. Alten, Julia
  13. Cario, Gunnar
  14. Schrappe, Martin
  15. Bergmann, Anke Katharina
  16. Stanulla, Martin
  17. Steinemann, Doris
  18. Schlegelberger, Brigitte
  19. Cazzaniga, Giovanni
  20. Göhring, Gudrun

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WeightNameValue
1000 Titel
  • Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia
1000 Autor/in
  1. Schieck, Maximilian |
  2. Lentes, Jana |
  3. Thomay, Kathrin |
  4. Hofmann, Winfried |
  5. Behrens, Yvonne Lisa |
  6. Hagedorn, Maike |
  7. Ebersold, Juliane |
  8. Davenport, Colin F. |
  9. Fazio, Grazia |
  10. Möricke, Anja |
  11. Buchmann, Swantje |
  12. Alten, Julia |
  13. Cario, Gunnar |
  14. Schrappe, Martin |
  15. Bergmann, Anke Katharina |
  16. Stanulla, Martin |
  17. Steinemann, Doris |
  18. Schlegelberger, Brigitte |
  19. Cazzaniga, Giovanni |
  20. Göhring, Gudrun |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-20
1000 Erschienen in
1000 Quellenangabe
  • 99(4):809-818
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00277-020-03953-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069912/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Risk-adapted therapy has significantly contributed to improved survival rates in pediatric acute lymphoblastic leukemia (ALL) and reliable detection of chromosomal aberrations is mandatory for risk group stratification. This study evaluated the applicability of panel-based RNA sequencing and array CGH within the diagnostic workflow of the German study group of the international AIEOP-BFM ALL 2017 trial. In a consecutive cohort of 117 children with B cell precursor (BCP) ALL, array analysis identified twelve cases with an IKZF1
1000 Sacherschließung
lokal Daunorubicin/administration
lokal Mercaptopurine/administration
lokal IKZF1plus
lokal RNA, Messenger/analysis [MeSH]
lokal Risk Factors [MeSH]
lokal Diagnostics
lokal Cyclophosphamide/administration
lokal Original Article
lokal RNA, Neoplasm/analysis [MeSH]
lokal Risk stratification
lokal Asparaginase/administration
lokal Fusion transcript
lokal Vincristine/administration
lokal Workflow [MeSH]
lokal Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Acute lymphoblastic leukemia
lokal Sequence Analysis, RNA [MeSH]
lokal Abnormal Karyotype [MeSH]
lokal Antineoplastic Combined Chemotherapy Protocols/administration
lokal Genes, Neoplasm [MeSH]
lokal Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH]
lokal Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy [MeSH]
lokal Prednisone/administration
lokal Neoplasm Proteins/genetics [MeSH]
lokal Ikaros Transcription Factor/genetics [MeSH]
lokal Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics [MeSH]
lokal Methotrexate/administration
lokal Comparative Genomic Hybridization [MeSH]
lokal RNA sequencing
lokal Transcriptome [MeSH]
lokal Cytarabine/administration
lokal In Situ Hybridization, Fluorescence [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5878-0546|https://frl.publisso.de/adhoc/uri/TGVudGVzLCBKYW5h|https://frl.publisso.de/adhoc/uri/VGhvbWF5LCBLYXRocmlu|https://frl.publisso.de/adhoc/uri/SG9mbWFubiwgV2luZnJpZWQ=|https://frl.publisso.de/adhoc/uri/QmVocmVucywgWXZvbm5lIExpc2E=|https://frl.publisso.de/adhoc/uri/SGFnZWRvcm4sIE1haWtl|https://frl.publisso.de/adhoc/uri/RWJlcnNvbGQsIEp1bGlhbmU=|https://frl.publisso.de/adhoc/uri/RGF2ZW5wb3J0LCBDb2xpbiBGLg==|https://frl.publisso.de/adhoc/uri/RmF6aW8sIEdyYXppYQ==|https://frl.publisso.de/adhoc/uri/TcO2cmlja2UsIEFuamE=|https://frl.publisso.de/adhoc/uri/QnVjaG1hbm4sIFN3YW50amU=|https://frl.publisso.de/adhoc/uri/QWx0ZW4sIEp1bGlh|https://frl.publisso.de/adhoc/uri/Q2FyaW8sIEd1bm5hcg==|https://frl.publisso.de/adhoc/uri/U2NocmFwcGUsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/QmVyZ21hbm4sIEFua2UgS2F0aGFyaW5h|https://frl.publisso.de/adhoc/uri/U3RhbnVsbGEsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/U3RlaW5lbWFubiwgRG9yaXM=|https://frl.publisso.de/adhoc/uri/U2NobGVnZWxiZXJnZXIsIEJyaWdpdHRl|https://frl.publisso.de/adhoc/uri/Q2F6emFuaWdhLCBHaW92YW5uaQ==|https://frl.publisso.de/adhoc/uri/R8O2aHJpbmcsIEd1ZHJ1bg==
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1000 Erstellt am 2023-11-17T04:54:40.849+0100
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1000 Zuletzt bearbeitet Fri Dec 01 05:11:45 CET 2023
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