The making of insulin in health and disease

  1. Vasiljević, Jovana ORCID logo
  2. Torkko, Juha M.
  3. Knoch, Klaus-Peter
  4. Solimena, Michele ORCID logo

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WeightNameValue
1000 Titel
  • The making of insulin in health and disease
1000 Autor/in
  1. Vasiljević, Jovana |
  2. Torkko, Juha M. |
  3. Knoch, Klaus-Peter |
  4. Solimena, Michele |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-07
1000 Erschienen in
1000 Quellenangabe
  • 63(10):1981-1989
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00125-020-05192-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476993/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. Graphical abstract.
1000 Sacherschließung
lokal Type 2 diabetes
lokal Post-transcriptional regulation
lokal Protein Precursors/genetics [MeSH]
lokal Type 1 diabetes
lokal Beta cell
lokal Insulin maturation
lokal Gene Expression Regulation [MeSH]
lokal Glucose/metabolism [MeSH]
lokal Insulin/genetics [MeSH]
lokal Insulin biosynthesis
lokal RNA Processing, Post-Transcriptional [MeSH]
lokal Proinsulin/biosynthesis [MeSH]
lokal RNA, Messenger/metabolism [MeSH]
lokal Protein Precursors/biosynthesis [MeSH]
lokal Proinsulin conversion
lokal Proinsulin/genetics [MeSH]
lokal Insulin/biosynthesis [MeSH]
lokal Humans [MeSH]
lokal Proinsulin/metabolism [MeSH]
lokal Protein Biosynthesis [MeSH]
lokal Protein Precursors/metabolism [MeSH]
lokal Protein Folding [MeSH]
lokal Insulin Secretion [MeSH]
lokal Review
lokal Diabetes Mellitus, Type 2/metabolism [MeSH]
lokal Diabetes Mellitus, Type 1/metabolism [MeSH]
lokal Secretory Vesicles/metabolism [MeSH]
lokal Crystallization [MeSH]
lokal Insulin/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5950-2011|https://frl.publisso.de/adhoc/uri/VG9ya2tvLCBKdWhhIE0u|https://frl.publisso.de/adhoc/uri/S25vY2gsIEtsYXVzLVBldGVy|https://orcid.org/0000-0002-3653-8107
1000 Hinweis
  • DeepGreen-ID: 05f2711ddc854dbaac4679bac6f47dfe ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
  1. The making of insulin in health and disease
    The making of insulin in health and disease
1000 Objektart article
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1000 Erstellt am 2023-11-17T19:56:09.023+0100
1000 Erstellt von 322
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1000 Zuletzt bearbeitet Fri Dec 01 09:06:04 CET 2023
1000 Objekt bearb. Fri Dec 01 09:06:04 CET 2023
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