BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes

  1. Peiffer, Lukas
  2. Farahpour, Farnoush
  3. Sriram, Ashwin
  4. Spassova, Ivelina
  5. Hoffmann, Daniel
  6. Kubat, Linda
  7. Stoitzner, Patrizia
  8. Gambichler, Thilo
  9. Sucker, Antje
  10. Ugurel, Selma
  11. Schadendorf, Dirk
  12. Becker, Jürgen ORCID logo

Download
s00262-020-02804-4.pdf 9,58MB
WeightNameValue
1000 Titel
  • BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
1000 Autor/in
  1. Peiffer, Lukas |
  2. Farahpour, Farnoush |
  3. Sriram, Ashwin |
  4. Spassova, Ivelina |
  5. Hoffmann, Daniel |
  6. Kubat, Linda |
  7. Stoitzner, Patrizia |
  8. Gambichler, Thilo |
  9. Sucker, Antje |
  10. Ugurel, Selma |
  11. Schadendorf, Dirk |
  12. Becker, Jürgen |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-04
1000 Erschienen in
1000 Quellenangabe
  • 70(6):1635-1647
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00262-020-02804-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139931/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Combined inhibition of BRAF/MEK is an established therapy for melanoma. In addition to its canonical mode of action, effects of BRAF/MEK inhibitors on antitumor immune responses are emerging. Thus, we investigated the effect of these on adaptive immune responses.!##!Patients, methods and results!#!Sequential tumor biopsies obtained before and during BRAF/MEK inhibitor treatment of four (n = 4) melanoma patients were analyzed. Multiplexed immunofluorescence staining of tumor tissue revealed an increased infiltration of CD4!##!Conclusions!#!Our results suggest that BRAF/MEK inhibition in melanoma patients allows an increased expansion of pre-existing melanoma-specific T cells by induction of T-bet and TCF7 in these.
1000 Sacherschließung
lokal Gene Expression Regulation, Neoplastic [MeSH]
lokal Melanoma/metabolism [MeSH]
lokal T-cell receptor repertoire
lokal Lymphocytes, Tumor-Infiltrating/drug effects [MeSH]
lokal Tumor microenvironment
lokal Original Article
lokal Tumor Cells, Cultured [MeSH]
lokal Melanoma/pathology [MeSH]
lokal Biomarkers, Tumor/analysis [MeSH]
lokal Melanoma/drug therapy [MeSH]
lokal CTA
lokal Cellular Reprogramming [MeSH]
lokal Proto-Oncogene Proteins B-raf/antagonists
lokal TCF7
lokal MDA
lokal Receptors, Antigen, T-Cell/metabolism [MeSH]
lokal Humans [MeSH]
lokal T Cell Transcription Factor 1/metabolism [MeSH]
lokal Protein Kinase Inhibitors/therapeutic use [MeSH]
lokal Lymphocytes, Tumor-Infiltrating/immunology [MeSH]
lokal T Cell Transcription Factor 1/genetics [MeSH]
lokal MAP Kinase Kinase 1/antagonists
lokal Melanoma/immunology [MeSH]
lokal Prognosis [MeSH]
lokal Receptors, Antigen, T-Cell/genetics [MeSH]
lokal BRAF/MEK inhibition
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UGVpZmZlciwgTHVrYXM=|https://frl.publisso.de/adhoc/uri/RmFyYWhwb3VyLCBGYXJub3VzaA==|https://frl.publisso.de/adhoc/uri/U3JpcmFtLCBBc2h3aW4=|https://frl.publisso.de/adhoc/uri/U3Bhc3NvdmEsIEl2ZWxpbmE=|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIERhbmllbA==|https://frl.publisso.de/adhoc/uri/S3ViYXQsIExpbmRh|https://frl.publisso.de/adhoc/uri/U3RvaXR6bmVyLCBQYXRyaXppYQ==|https://frl.publisso.de/adhoc/uri/R2FtYmljaGxlciwgVGhpbG8=|https://frl.publisso.de/adhoc/uri/U3Vja2VyLCBBbnRqZQ==|https://frl.publisso.de/adhoc/uri/VWd1cmVsLCBTZWxtYQ==|https://frl.publisso.de/adhoc/uri/U2NoYWRlbmRvcmYsIERpcms=|https://orcid.org/0000-0001-9183-653X
1000 Hinweis
  • DeepGreen-ID: 651230bb32d74b678ed34b9c8c1d001b ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6470082.rdf
1000 Erstellt am 2023-11-18T03:45:47.737+0100
1000 Erstellt von 322
1000 beschreibt frl:6470082
1000 Zuletzt bearbeitet Fri Dec 01 11:07:37 CET 2023
1000 Objekt bearb. Fri Dec 01 11:07:37 CET 2023
1000 Vgl. frl:6470082
1000 Oai Id
  1. oai:frl.publisso.de:frl:6470082 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source