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1000 Titel
  • Prediction of survival in patients with IDH-wildtype astrocytic gliomas using dynamic O-(2-[18F]-fluoroethyl)-l-tyrosine PET
1000 Autor/in
  1. Bauer, Elena K. |
  2. Stoffels, Gabriele |
  3. Blau, Tobias |
  4. Reifenberger, Guido |
  5. Felsberg, Jörg |
  6. Werner, Jan M. |
  7. Lohmann, Philipp |
  8. Rosen, Jurij |
  9. Ceccon, Garry |
  10. Tscherpel, Caroline |
  11. Rapp, Marion |
  12. Sabel, Michael |
  13. Filss, Christian P. |
  14. Shah, Nadim J. |
  15. Neumaier, Bernd |
  16. Fink, Gereon R. |
  17. Langen, Karl-Josef |
  18. Galldiks, Norbert |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-07
1000 Erschienen in
1000 Quellenangabe
  • 47(6):1486-1495
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-04695-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188701/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Integrated histomolecular diagnostics of gliomas according to the World Health Organization (WHO) classification of 2016 has refined diagnostic accuracy and prediction of prognosis. This study aimed at exploring the prognostic value of dynamic O-(2-[!##!Methods!#!Before initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumour/brain ratios (TBR!##!Results!#!Sixty patients (45 GBM and 15 AA patients) of two university centres were retrospectively identified. Patients with isocitrate dehydrogenase (IDH)-mutant or O!##!Conclusions!#!Our data suggest that dynamic FET PET allows the identification of patients with longer OS among patients with newly diagnosed IDH-wildtype GBM and AA.
1000 Sacherschließung
lokal Neoplasm Grading [MeSH]
lokal Brain Neoplasms/genetics [MeSH]
lokal FET PET
lokal Humans [MeSH]
lokal Oncology - Brain
lokal Overall survival
lokal Retrospective Studies [MeSH]
lokal IDH mutation
lokal Original Article
lokal High-grade glioma
lokal Astrocytoma/diagnostic imaging [MeSH]
lokal Positron-Emission Tomography [MeSH]
lokal Tyrosine [MeSH]
lokal Astrocytoma/genetics [MeSH]
lokal Brain Neoplasms/diagnostic imaging [MeSH]
lokal MGMT promoter methylation
lokal Isocitrate Dehydrogenase/genetics [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QmF1ZXIsIEVsZW5hIEsu|https://frl.publisso.de/adhoc/uri/U3RvZmZlbHMsIEdhYnJpZWxl|https://frl.publisso.de/adhoc/uri/QmxhdSwgVG9iaWFz|https://frl.publisso.de/adhoc/uri/UmVpZmVuYmVyZ2VyLCBHdWlkbw==|https://frl.publisso.de/adhoc/uri/RmVsc2JlcmcsIErDtnJn|https://frl.publisso.de/adhoc/uri/V2VybmVyLCBKYW4gTS4=|https://frl.publisso.de/adhoc/uri/TG9obWFubiwgUGhpbGlwcA==|https://frl.publisso.de/adhoc/uri/Um9zZW4sIEp1cmlq|https://frl.publisso.de/adhoc/uri/Q2VjY29uLCBHYXJyeQ==|https://frl.publisso.de/adhoc/uri/VHNjaGVycGVsLCBDYXJvbGluZQ==|https://frl.publisso.de/adhoc/uri/UmFwcCwgTWFyaW9u|https://frl.publisso.de/adhoc/uri/U2FiZWwsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/Rmlsc3MsIENocmlzdGlhbiBQLg==|https://frl.publisso.de/adhoc/uri/U2hhaCwgTmFkaW0gSi4=|https://frl.publisso.de/adhoc/uri/TmV1bWFpZXIsIEJlcm5k|https://frl.publisso.de/adhoc/uri/RmluaywgR2VyZW9uIFIu|https://frl.publisso.de/adhoc/uri/TGFuZ2VuLCBLYXJsLUpvc2Vm|https://orcid.org/0000-0002-2485-1796
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1000 Erstellt am 2023-11-18T04:42:27.233+0100
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