Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms

  1. Giaccherini, Matteo ORCID logo
  2. Macauda, Angelica
  3. Sgherza, Nicola ORCID logo
  4. SAINZ, JUAN ORCID logo
  5. Gemignani, Federica
  6. Maldonado, Josè Manuel Sanchez
  7. Jurado, Manuel
  8. Tavano, Francesca
  9. Mazur, Grzegorz
  10. Jerez, Andrés
  11. Góra-Tybor, Joanna
  12. Gołos, Aleksandra ORCID logo
  13. Mohedo, Francisca Hernández
  14. Martinez-Lopez, Joaquin ORCID logo
  15. Várkonyi, Judit
  16. Spadano, Raffaele
  17. Butrym, Aleksandra
  18. Canzian, Federico ORCID logo
  19. Campa, Daniele

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1000 Titel
  • Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms
1000 Autor/in
  1. Giaccherini, Matteo |
  2. Macauda, Angelica |
  3. Sgherza, Nicola |
  4. SAINZ, JUAN |
  5. Gemignani, Federica |
  6. Maldonado, Josè Manuel Sanchez |
  7. Jurado, Manuel |
  8. Tavano, Francesca |
  9. Mazur, Grzegorz |
  10. Jerez, Andrés |
  11. Góra-Tybor, Joanna |
  12. Gołos, Aleksandra |
  13. Mohedo, Francisca Hernández |
  14. Martinez-Lopez, Joaquin |
  15. Várkonyi, Judit |
  16. Spadano, Raffaele |
  17. Butrym, Aleksandra |
  18. Canzian, Federico |
  19. Campa, Daniele |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-01
1000 Erschienen in
1000 Quellenangabe
  • 10(8):89
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41408-020-00356-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463014/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 SNPs previously shown to influence LTL. Their combination in a score has been used as a genetic instrument to measure LTL and evaluate the causative association between LTL and the risk of several cancer types. We tested, for the first time, the 'teloscore' in 480 MPN patients and 909 healthy controls in a European multi-center case-control study. We found an increased risk to develop MPNs with longer genetically determined telomeres (OR = 1.82, 95% CI 1.24-2.68, P = 2.21 × 10
1000 Sacherschließung
lokal Genetic Predisposition to Disease [MeSH]
lokal Female [MeSH]
lokal Aged [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Humans [MeSH]
lokal Telomere Homeostasis [MeSH]
lokal Middle Aged [MeSH]
lokal Risk Factors [MeSH]
lokal Risk factors
lokal Epidemiology
lokal Article
lokal Male [MeSH]
lokal Myeloproliferative Disorders/etiology [MeSH]
lokal Myeloproliferative Disorders/genetics [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-0363-6632|https://frl.publisso.de/adhoc/uri/TWFjYXVkYSwgQW5nZWxpY2E=|https://orcid.org/0000-0001-5447-1068|https://orcid.org/0000-0002-9355-2423|https://frl.publisso.de/adhoc/uri/R2VtaWduYW5pLCBGZWRlcmljYQ==|https://frl.publisso.de/adhoc/uri/TWFsZG9uYWRvLCBKb3PDqCBNYW51ZWwgU2FuY2hleg==|https://frl.publisso.de/adhoc/uri/SnVyYWRvLCBNYW51ZWw=|https://frl.publisso.de/adhoc/uri/VGF2YW5vLCBGcmFuY2VzY2E=|https://frl.publisso.de/adhoc/uri/TWF6dXIsIEdyemVnb3J6|https://frl.publisso.de/adhoc/uri/SmVyZXosIEFuZHLDqXM=|https://frl.publisso.de/adhoc/uri/R8OzcmEtVHlib3IsIEpvYW5uYQ==|https://orcid.org/0000-0002-7780-3587|https://frl.publisso.de/adhoc/uri/TW9oZWRvLCBGcmFuY2lzY2EgSGVybsOhbmRleg==|https://orcid.org/0000-0001-7908-0063|https://frl.publisso.de/adhoc/uri/VsOhcmtvbnlpLCBKdWRpdA==|https://frl.publisso.de/adhoc/uri/U3BhZGFubywgUmFmZmFlbGU=|https://frl.publisso.de/adhoc/uri/QnV0cnltLCBBbGVrc2FuZHJh|https://orcid.org/0000-0002-4261-4583|https://frl.publisso.de/adhoc/uri/Q2FtcGEsIERhbmllbGU=
1000 Hinweis
  • DeepGreen-ID: a92797e69e5a4e429586d9610507d579 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-18T19:00:02.757+0100
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1000 Zuletzt bearbeitet Wed Apr 03 13:29:45 CEST 2024
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