Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4

  1. Badowska, Dorota ORCID logo
  2. Brzozka, Magdalena M. ORCID logo
  3. Kannaiyan, Nirmal Raman ORCID logo
  4. Thomas, Carolina ORCID logo
  5. Dibaj, P.
  6. Chowdhury, A.
  7. Steffens, H.
  8. Turck, C. W.
  9. Falkai, P.
  10. Schmitt, A.
  11. Papiol, S.
  12. Scheuss, V.
  13. Willig, Katrin ORCID logo
  14. Martins-de-Souza, D.
  15. Rhee, J. S.
  16. Malzahn, D.
  17. Rossner, Moritz ORCID logo

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WeightNameValue
1000 Titel
  • Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4
1000 Autor/in
  1. Badowska, Dorota |
  2. Brzozka, Magdalena M. |
  3. Kannaiyan, Nirmal Raman |
  4. Thomas, Carolina |
  5. Dibaj, P. |
  6. Chowdhury, A. |
  7. Steffens, H. |
  8. Turck, C. W. |
  9. Falkai, P. |
  10. Schmitt, A. |
  11. Papiol, S. |
  12. Scheuss, V. |
  13. Willig, Katrin |
  14. Martins-de-Souza, D. |
  15. Rhee, J. S. |
  16. Malzahn, D. |
  17. Rossner, Moritz |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-10-09
1000 Erschienen in
1000 Quellenangabe
  • 10(1):343
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-020-01026-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547694/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The transcription factor TCF4 was confirmed in several large genome-wide association studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic mice moderately overexpressing Tcf4 in forebrain (Tcf4tg) display deficits in fear memory and sensorimotor gating. As second hit, we exposed Tcf4tg animals to isolation rearing (IR), chronic social defeat (SD), enriched environment (EE), or handling control (HC) conditions and examined mice with heterozygous deletion of the exon 4 (Tcf4Ex4δ
1000 Sacherschließung
lokal Mice, Transgenic [MeSH]
lokal Mice [MeSH]
lokal Schizophrenia/genetics [MeSH]
lokal Article
lokal Proteomics [MeSH]
lokal Molecular neuroscience
lokal Neuronal Plasticity/genetics [MeSH]
lokal Psychiatric disorders
lokal Cognition [MeSH]
lokal Animals [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Genome-Wide Association Study [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6234-582X|https://orcid.org/0000-0001-8633-2855|https://orcid.org/0000-0002-7408-6842|https://orcid.org/0000-0002-7386-1181|https://frl.publisso.de/adhoc/uri/RGliYWosIFAu|https://frl.publisso.de/adhoc/uri/Q2hvd2RodXJ5LCBBLg==|https://frl.publisso.de/adhoc/uri/U3RlZmZlbnMsIEgu|https://frl.publisso.de/adhoc/uri/VHVyY2ssIEMuIFcu|https://frl.publisso.de/adhoc/uri/RmFsa2FpLCBQLg==|https://frl.publisso.de/adhoc/uri/U2NobWl0dCwgQS4=|https://frl.publisso.de/adhoc/uri/UGFwaW9sLCBTLg==|https://frl.publisso.de/adhoc/uri/U2NoZXVzcywgVi4=|https://orcid.org/0000-0002-1860-334X|https://frl.publisso.de/adhoc/uri/TWFydGlucy1kZS1Tb3V6YSwgRC4=|https://frl.publisso.de/adhoc/uri/UmhlZSwgSi4gUy4=|https://frl.publisso.de/adhoc/uri/TWFsemFobiwgRC4=|https://orcid.org/0000-0002-0667-3420
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1000 Erstellt am 2023-11-18T19:02:23.599+0100
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