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1000 Titel
  • The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α?
1000 Autor/in
  1. Koch, Andreas |
  2. Kähler, Wataru |
  3. Klapa, Sebastian |
  4. Grams, Bente |
  5. van Ooij, Pieter- Jan A. M. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-15
1000 Erschienen in
1000 Quellenangabe
  • 8(1):53
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40635-020-00323-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490775/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Chronic Patellar tendinopathy (CPT) is a frequent overuse disorder in athletes and active people. Sclerotherapy (ST) and prolotherapy (PT) are, among a wide range of conservative treatment options, two promising therapies and have shown positive results in other tendinopathies. Since the treatments' efficacy and safety are still not defined, this review sought to answer questions on recommendations for use in clinical utility, safety, and how to perform the injection in the most effective way. An electronic database search was conducted following the PRISMA guidelines. Inclusion criteria were set up according to the PICOS-scheme. Included were athletes and non-athletes of all ages with diagnosed painful CPT. Studies including patients suffering from patellar tendinopathy which can be originated to any systemic condition affecting the musculoskeletal system (e.g. disorders associated with rheumatism) and animal studies were excluded. Methodological quality (modified Coleman Methodology Score) and risk of bias (Cochrane Risk of Bias Assessment Tool 2.0) were assessed by two independent reviewers, with disagreements resolved with a third reviewer. The search yielded a total of 416 entries. After screening titles, abstracts, and full texts, ten articles were found for qualitative analysis. The mean Coleman Score was 64.57. Three randomized-controlled trials showed positive results with an increase in VISA-P score or a decrease in VAS or NPPS, respectively. The non-randomized studies confirmed the positive results as well. Among all ten studies no serious adverse events were reported. Based on this limited set of studies, there seems to be some evidence that ST and PT may be effective treatment options to treat pain and to improve function in patients with CPT. To strengthen this recommendation, more research is needed with larger volume studies and randomized controlled studies with long term follow up. LEVEL OF EVIDENCE: IV.
1000 Sacherschließung
lokal Intensive / Critical Care Medicine
lokal Hypothesis
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S29jaCwgQW5kcmVhcw==|https://frl.publisso.de/adhoc/uri/S8OkaGxlciwgV2F0YXJ1|https://frl.publisso.de/adhoc/uri/S2xhcGEsIFNlYmFzdGlhbg==|https://frl.publisso.de/adhoc/uri/R3JhbXMsIEJlbnRl|https://frl.publisso.de/adhoc/uri/dmFuIE9vaWosIFBpZXRlci0gSmFuIEEuIE0u
1000 Hinweis
  • DeepGreen-ID: 2a8b456e81834a93b5d1bbb2bd46865e ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6472326.rdf
1000 Erstellt am 2023-11-18T19:39:15.549+0100
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2024-04-05T13:11:33.393+0200
1000 Objekt bearb. Fri Apr 05 13:11:33 CEST 2024
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6472326 |
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