Evidence for a shared genetic contribution to loneliness and borderline personality disorder

  1. Schulze, Anna ORCID logo
  2. Streit, Fabian ORCID logo
  3. Zillich, Lea ORCID logo
  4. Awasthi, Swapnil
  5. Hall, Alisha S. M.
  6. Jungkunz, Martin
  7. Kleindienst, Nikolaus
  8. Frank, Josef ORCID logo
  9. Schwarze, Cornelia E.
  10. Dahmen, Norbert
  11. Schott, Björn ORCID logo
  12. Nöthen, Markus ORCID logo
  13. Mobascher, Arian
  14. Rujescu, Dan ORCID logo
  15. Lieb, Klaus
  16. Roepke, Stefan ORCID logo
  17. Herpertz, Sabine C.
  18. Schmahl, Christian
  19. Bohus, Martin
  20. Ripke, Stephan
  21. Rietschel, Marcella ORCID logo
  22. Lis, Stefanie ORCID logo
  23. Witt, Stephanie ORCID logo

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WeightNameValue
1000 Titel
  • Evidence for a shared genetic contribution to loneliness and borderline personality disorder
1000 Autor/in
  1. Schulze, Anna |
  2. Streit, Fabian |
  3. Zillich, Lea |
  4. Awasthi, Swapnil |
  5. Hall, Alisha S. M. |
  6. Jungkunz, Martin |
  7. Kleindienst, Nikolaus |
  8. Frank, Josef |
  9. Schwarze, Cornelia E. |
  10. Dahmen, Norbert |
  11. Schott, Björn |
  12. Nöthen, Markus |
  13. Mobascher, Arian |
  14. Rujescu, Dan |
  15. Lieb, Klaus |
  16. Roepke, Stefan |
  17. Herpertz, Sabine C. |
  18. Schmahl, Christian |
  19. Bohus, Martin |
  20. Ripke, Stephan |
  21. Rietschel, Marcella |
  22. Lis, Stefanie |
  23. Witt, Stephanie |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-12-18
1000 Erschienen in
1000 Quellenangabe
  • 13(1):398
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-023-02705-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10725864/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41398-023-02705-x#Sec21 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Loneliness, influenced by genetic and environmental factors such as childhood maltreatment, is one aspect of interpersonal dysfunction in Borderline Personality Disorder (BPD). Numerous studies link loneliness and BPD and twin studies indicate a genetic contribution to this association. The aim of our study was to investigate whether genetic predisposition for loneliness and BPD risk overlap and whether genetic risk for loneliness contributes to higher loneliness reported by BPD patients, using genome-wide genotype data. We assessed the genetic correlation of genome-wide association studies (GWAS) of loneliness and BPD using linkage disequilibrium score regression and tested whether a polygenic score for loneliness (loneliness-PGS) was associated with case-control status in two independent genotyped samples of BPD patients and healthy controls (HC; Witt2017-sample: 998 BPD, 1545 HC; KFO-sample: 187 BPD, 261 HC). In the KFO-sample, we examined associations of loneliness-PGS with reported loneliness, and whether the loneliness-PGS influenced the association between childhood maltreatment and loneliness. We found a genetic correlation between the GWAS of loneliness and BPD in the Witt2017-sample (rg = 0.23, p = 0.015), a positive association of loneliness-PGS with BPD case-control status (Witt2017-sample: NkR² = 2.3%, p = 2.7*10-12; KFO-sample: NkR² = 6.6%, p = 4.4*10-6), and a positive association between loneliness-PGS and loneliness across patient and control groups in the KFO-sample (β = 0.186, p = 0.002). The loneliness-PGS did not moderate the association between childhood maltreatment and loneliness in BPD. Our study is the first to use genome-wide genotype data to show that the genetic factors underlying variation in loneliness in the general population and the risk for BPD overlap. The loneliness-PGS was associated with reported loneliness. Further research is needed to investigate which genetic mechanisms and pathways are involved in this association and whether a genetic predisposition for loneliness contributes to BPD risk.
1000 Sacherschließung
lokal Psychiatric disorders
lokal Clinical genetics
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5584-154X|https://orcid.org/0000-0003-1080-4339|https://orcid.org/0000-0001-7457-374X|https://frl.publisso.de/adhoc/uri/QXdhc3RoaSwgU3dhcG5pbA==|https://frl.publisso.de/adhoc/uri/SGFsbCwgQWxpc2hhIFMuIE0u|https://frl.publisso.de/adhoc/uri/SnVuZ2t1bnosIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/S2xlaW5kaWVuc3QsIE5pa29sYXVz|https://orcid.org/0000-0003-4867-9465|https://frl.publisso.de/adhoc/uri/U2Nod2FyemUsIENvcm5lbGlhIEUu|https://frl.publisso.de/adhoc/uri/RGFobWVuLCBOb3JiZXJ0|https://orcid.org/0000-0002-8237-4481|https://orcid.org/0000-0002-8770-2464|https://frl.publisso.de/adhoc/uri/TW9iYXNjaGVyLCBBcmlhbg==|https://orcid.org/0000-0002-1432-313X|https://frl.publisso.de/adhoc/uri/TGllYiwgS2xhdXM=|https://orcid.org/0000-0003-3165-8684|https://frl.publisso.de/adhoc/uri/SGVycGVydHosIFNhYmluZSBDLg==|https://frl.publisso.de/adhoc/uri/U2NobWFobCwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/Qm9odXMsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/Umlwa2UsIFN0ZXBoYW4=|https://orcid.org/0000-0002-5236-6149|https://orcid.org/0000-0002-8051-2756|https://orcid.org/0000-0002-1571-1468
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Universität Heidelberg |
  3. Projekt DEAL |
1000 Fördernummer
  1. KFO-256; GRK2350/3 – 324164820
  2. -
  3. -
1000 Förderprogramm
  1. Open Access Publikationskosten
  2. -
  3. Open Access funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm Open Access Publikationskosten
    1000 Fördernummer KFO-256; GRK2350/3 – 324164820
  2. 1000 joinedFunding-child
    1000 Förderer Universität Heidelberg |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6473426.rdf
1000 Erstellt am 2024-03-08T11:21:15.085+0100
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