Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

  1. Siemens, Nikolai
  2. Oehmcke-Hecht, Sonja
  3. Hoßmann, Jörn
  4. Skorka, Sebastian B.
  5. Nijhuis, Roel H.T.
  6. Ruppen, Corinne
  7. Skrede, Steinar
  8. Rohde, Manfred
  9. Schultz, Daniel
  10. Lalk, Michael
  11. Itzek, Andreas
  12. Pieper, Dietmar H.
  13. van den Bout, Christiaan J.
  14. Claas, Eric C.J.
  15. Kuijper, Ed J.
  16. Mauritz, Robert
  17. Sendi, Parham
  18. Wunderink, Herman F.
  19. Norrby-Teglund, Anna

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1000 Titel
  • Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment
1000 Autor/in
  1. Siemens, Nikolai |
  2. Oehmcke-Hecht, Sonja |
  3. Hoßmann, Jörn |
  4. Skorka, Sebastian B. |
  5. Nijhuis, Roel H.T. |
  6. Ruppen, Corinne |
  7. Skrede, Steinar |
  8. Rohde, Manfred |
  9. Schultz, Daniel |
  10. Lalk, Michael |
  11. Itzek, Andreas |
  12. Pieper, Dietmar H. |
  13. van den Bout, Christiaan J. |
  14. Claas, Eric C.J. |
  15. Kuijper, Ed J. |
  16. Mauritz, Robert |
  17. Sendi, Parham |
  18. Wunderink, Herman F. |
  19. Norrby-Teglund, Anna |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-11-19
1000 Erschienen in
1000 Quellenangabe
  • 12(4):291-303
1000 Copyrightjahr
  • 2019
1000 Embargo
  • 2020-11-25
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1159/000504002 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383282/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.
1000 Sacherschließung
lokal Group B streptococcus
lokal Hemolysis
lokal Thrombosis/microbiology [MeSH]
lokal Thrombosis/genetics [MeSH]
lokal Interleukin-6/immunology [MeSH]
lokal Pigment
lokal Pigments, Biological/toxicity [MeSH]
lokal Streptococcal Infections/pathology [MeSH]
lokal Leukocytes/microbiology [MeSH]
lokal Pigments, Biological/genetics [MeSH]
lokal Streptococcal Infections/immunology [MeSH]
lokal Coagulation
lokal Bacterial Toxins/toxicity [MeSH]
lokal Streptococcal Infections/genetics [MeSH]
lokal Research Article
lokal Interleukin-1beta/immunology [MeSH]
lokal Pigments, Biological/immunology [MeSH]
lokal Streptococcus agalactiae/genetics [MeSH]
lokal Streptococcus agalactiae/immunology [MeSH]
lokal Thrombosis/pathology [MeSH]
lokal Leukocytes/immunology [MeSH]
lokal Humans [MeSH]
lokal Inflammation
lokal Bacterial Toxins/genetics [MeSH]
lokal Thrombosis/immunology [MeSH]
lokal Bacterial Toxins/immunology [MeSH]
lokal Hemolysis/immunology [MeSH]
lokal Leukocytes/pathology [MeSH]
lokal Streptococcus agalactiae/pathogenicity [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2024-04-11T13:18:14.092+0200
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