Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue

  1. Félix, Inês
  2. Jokela, Heli
  3. Karhula, Joonas
  4. Kotaja, Noora
  5. Savontaus, Eriika
  6. Salmi, Marko
  7. Rantakari, Pia

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1000 Titel
  • Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue
1000 Autor/in
  1. Félix, Inês |
  2. Jokela, Heli |
  3. Karhula, Joonas |
  4. Kotaja, Noora |
  5. Savontaus, Eriika |
  6. Salmi, Marko |
  7. Rantakari, Pia |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-26
1000 Erschienen in
1000 Quellenangabe
  • 12
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-28
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2021.719979 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350344/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • Adipose tissue macrophages (ATMs) regulate homeostasis and contribute to the metabolically harmful chronic inflammation in obese individuals. While evident heterogeneity of resident ATMs has been described previously, their phenotype, developmental origin, and functionality remain inconsistent. We analyzed white adipose tissue (WAT) during homeostasis and diet interventions using comprehensive and unbiased single-cell mass cytometry and genetic lineage tracking models. We now provide a uniform definition of individual subsets of resident ATMs. We show that in lean mice, WAT co-harbors eight kinetically evolving CD206
1000 Sacherschließung
lokal Adipose Tissue, White/immunology [MeSH]
lokal adipose tissue
lokal Cell Differentiation [MeSH]
lokal Macrophages/metabolism [MeSH]
lokal developmental origin
lokal obesity
lokal Obesity/pathology [MeSH]
lokal Models, Animal [MeSH]
lokal Macrophages/immunology [MeSH]
lokal Obesity/metabolism [MeSH]
lokal Phagocytosis [MeSH]
lokal Cell Plasticity/genetics [MeSH]
lokal Energy Metabolism [MeSH]
lokal Male [MeSH]
lokal Immunophenotyping [MeSH]
lokal mass cytometry (CyTOF)
lokal Adipose Tissue, White/metabolism [MeSH]
lokal macrophage
lokal Computational Biology [MeSH]
lokal Cellular Reprogramming [MeSH]
lokal Adipose Tissue/immunology [MeSH]
lokal Immunology
lokal Proteomics/methods [MeSH]
lokal Animals [MeSH]
lokal Mice, Knockout [MeSH]
lokal Immunohistochemistry [MeSH]
lokal Mice [MeSH]
lokal Proteome/metabolism [MeSH]
lokal Single-Cell Analysis/methods [MeSH]
lokal Obesity/etiology [MeSH]
lokal Adipose Tissue/metabolism [MeSH]
lokal Biomarkers [MeSH]
lokal Cell Plasticity/immunology [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RsOpbGl4LCBJbsOqcw==|https://frl.publisso.de/adhoc/uri/Sm9rZWxhLCBIZWxp|https://frl.publisso.de/adhoc/uri/S2FyaHVsYSwgSm9vbmFz|https://frl.publisso.de/adhoc/uri/S290YWphLCBOb29yYQ==|https://frl.publisso.de/adhoc/uri/U2F2b250YXVzLCBFcmlpa2E=|https://frl.publisso.de/adhoc/uri/U2FsbWksIE1hcmtv|https://frl.publisso.de/adhoc/uri/UmFudGFrYXJpLCBQaWE=
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1000 Erstellt am 2024-04-11T13:34:39.928+0200
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1000 Zuletzt bearbeitet Tue May 07 14:29:24 CEST 2024
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