The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.

Sacherschließung

lokal	Humans
lokal	Mutation [MeSH]
lokal	Squalene Monooxygenase/metabolism
lokal	Mutation
lokal	Terbinafine
lokal	Humans [MeSH]
lokal	Colorectal Neoplasms/drug therapy [MeSH]
lokal	Tumor Suppressor Protein p53/genetics
lokal	Tumor Suppressor Protein p53/genetics [MeSH]
lokal	Squalene Monooxygenase/metabolism [MeSH]
lokal	Colorectal Neoplasms/drug therapy
lokal	Colorectal Neoplasms/genetics
lokal	Colorectal Neoplasms/genetics [MeSH]
lokal	Squalene Monooxygenase/genetics
lokal	Terbinafine [MeSH]
lokal	Squalene Monooxygenase/genetics [MeSH]

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