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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

2016 . Dahms, Sven O. | Arciniega, Marcelino | Steinmetzer, Torsten | Huber, Robert | Than, Manuel

Desialylation of Spermatozoa and Epithelial Cell Glycocalyx Is a Consequence of Bacterial Infection of the Epididymis

2016 . Khosravi, Farhad | Michel, Vera | Galuska, Christina E. | Bhushan, Sudhanshu | Christian, Philipp | Schuppe, Hans-Christian | Pilatz, Adrian | Galuska, Sebastian P. | Meinhardt, Andreas

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication

2016 . Frontzek, Karl | Pfammatter, Manuela | Sorce, Silvia | Senatore, Assunta | Schwarz, Petra | Moos, Rita | Frauenknecht, Katrin | Hornemann, Simone | Aguzzi, Adriano

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity

2016 . Mesén-Ramírez, Paolo | Reinsch, Ferdinand | Blancke Soares, Alexandra | Bergmann, Bärbel | Ullrich, Ann-Katrin | Tenzer, Stefan | Spielmann, Tobias

SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6

2016 . Li, Shih-Wen | Wang, Ching-Ying | Jou, Yu-Jen | Huang, Su-Hua | Hsiao, Li-Hsin | Wan, Lei | Lin, Ying-Ju | Kung, Szu-Hao | Lin, Cheng-Wen

Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis

2016 . Coburger, Ina | Schaub, Yvonne | Roeser, Dirk | Hardes, Kornelia | Maeder, Patrick | Klee, Nina | Steinmetzer, Torsten | Imhof, Diana | Diederich, Wibke E. | Than, Manuel E.

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

2016 . Fritsch, Jürgen | Fickers, Ricarda | Klawitter, Jan | Särchen, Vinzenz | Zingler, Philipp | Adam, Dieter | Janssen, Ottmar | Krause, Eberhard | Schütze, Stefan

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers

2016 . Dahms, Sven O. | Creemers, John W. M. | Schaub, Yvonne | Bourenkov, Gleb P. | Zögg, Thomas | Brandstetter, Hans | Than, Manuel