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Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion

2021 . Kadioglu, Onat | Saeed, Mohamed | Mahmoud, Nuha | Azawi, Shaymaa | Mrasek, Kristin | Liehr, Thomas | Efferth, Thomas

The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro

2021 . , | Kondadi, Arun Kumar | Tsigaras, Thanos | von Montfort, Claudia | Graf, Peter | Stahl, Wilhelm | Brenneisen, Peter

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach

2021 . Alarcan, Jimmy | de Sousa, Georges | Katsanou, Efrosini S. | Spyropoulou, Anastasia | Batakis, Petros | Machera, Kyriaki | Rahmani, Roger | Lampen, Alfonso | Braeuning, Albert | Lichtenstein, Dajana

Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro

2021 . Steinritz, Dirk | Lüling, Robin | Siegert, Markus | Mückter, Harald | Popp, Tanja | Reinemer, Peter | Gudermann, Thomas | Thiermann, Horst | John, Harald

Post-VX exposure treatment of rats with engineered phosphotriesterases

2021 . Stigler, Lisa | Köhler, Anja | Koller, Marianne | Job, Laura | Escher, Benjamin | Potschka, Heidrun | Thiermann, Horst | Skerra, Arne | Worek, Franz | Wille, Timo

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

The enzyme subunit SubA of Shiga toxin-producing E. coli strains demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB in HeLa and HCT116 cells in vitro

2021 . Sessler, Katharina | Papatheodorou, Panagiotis | Wondany, Fanny | Krause, Maike | Noettger, Sabrina | Bernhard, Denise | Michaelis, Jens | Schmidt, Herbert | Barth, Holger

Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium

2021 . Probst, Stephanie | Fels, Johannes | Scharner, Bettina | Wolff, Natascha A. | Roussa, Eleni | van Swelm, Rachel | Lee, Wing-Kee | Thévenod, Frank