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Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion

2021 . Kadioglu, Onat | Saeed, Mohamed | Mahmoud, Nuha | Azawi, Shaymaa | Mrasek, Kristin | Liehr, Thomas | Efferth, Thomas

The EMA assessment of pembrolizumab as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer

2021 . Trullas, Ana | Delgado, Juan | Genazzani, Armando | Müller-Berghaus, Jan | Migali, Cristina | Müller-Egert, Susanne | Zander, Hilke | Enzmann, Harald | Pignatti, Francesco

DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with 131I

2021 . Schumann, S. | Scherthan, H. | Pfestroff, K. | Schoof, S. | Pfestroff, A. | Hartrampf, P. | Hasenauer, N. | Buck, A. K. | Luster, M. | Port, M. | Lassmann, M. | Eberlein, U.

Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L

2021 . Nathansen, Jacqueline | Lukiyanchuk, Vasyl | Hein, Linda | Stolte, Maya-Isabel | Borgmann, Kerstin | Löck, Steffen | Kurth, Ina | Baumann, Michael | Krause, Mechthild | Linge, Annett | Dubrovska, Anna

Effect of cryopreservation on DNA damage and DNA repair activity in human blood samples in the comet assay

2021 . Bankoglu, Ezgi Eylül | Stipp, Franzisca | Gerber, Johanna | Seyfried, Florian | Heidland, August | Bahner, Udo | Stopper, Helga

Mining for Perchlorate Resistance Genes in Microorganisms From Sediments of a Hypersaline Pond in Atacama Desert, Chile

2021 . Díaz-Rullo, Jorge | Rodríguez-Valdecantos, Gustavo | Torres-Rojas, Felipe | Cid, Luis | Vargas, Ignacio T. | González, Bernardo | González-Pastor, José Eduardo

The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

2021 . Siller, Sebastian | Lauseker, Michael | Karschnia, Philipp | Niyazi, Maximilian | Eigenbrod, Sabina | Giese, Armin | Tonn, Joerg-Christian

Does positive MGMT methylation outbalance the limitation of subtotal resection in glioblastoma IDH-wildtype patients?

2021 . Mareike, Müller | Staub-Bartelt, Franziska | Julia, Ehrmann | Daniel, Hänggi | Michael, Sabel | Jörg, Felsberg | Marion, Rapp

The N-terminal BRCT domain determines MCPH1 function in brain development and fertility

2021 . Liu, Xiaoqian | Schneble-Löhnert , Nadine | Kristofova, Martina | Qing, Xiaobing | Labisch, Jan | Hofmann , Susanne | Ehrenberg, Sandra | Sannai, Mara | Jörß, Tjard | Ori, Alessandro | Godmann, Maren | wang, zhao-qi

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3

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