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Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L

2021 . Nathansen, Jacqueline | Lukiyanchuk, Vasyl | Hein, Linda | Stolte, Maya-Isabel | Borgmann, Kerstin | Löck, Steffen | Kurth, Ina | Baumann, Michael | Krause, Mechthild | Linge, Annett | Dubrovska, Anna

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis

2021 . Kobelt, Dennis | Perez Hernandez, Daniel | Fleuter, Claudia | Dahlmann, Mathias | Zincke, Fabian | Smith, Janice | Migotti, Rebekka | Popp, Oliver | Burock, Susen | Walther, Wolfgang | Dittmar, Gunnar | Mertins, Philipp | Stein, Ulrike

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53

p53 partial loss-of-function mutations sensitize to chemotherapy

2021 . Klimovich, Boris | Merle, Nastasja | Neumann, Michelle | Elmshäuser, Sabrina | Nist, Andrea | Mernberger, Marco | Kazdal, Daniel | Stenzinger, Albrecht | Timofeev, Oleg | Stiewe, Thorsten

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression