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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition

2024 . Nath, Kavindra | Gupta, Pradeep K. | Basappa, Johnvesly | Wang, Shengchun | Sen, Neil | Lobello, Cosimo | Tomar, Jyoti S. | Shestov, Alexander A. | Orlovskiy, Stepan | Arias-Mendoza, Fernando | Rauert-Wunderlich, Hilka | Nelson, David S. | Glickson, Jerry D. | Wasik, Mariusz A.

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

2024 . Borlak, Juergen | Ciribilli, Yari | Bisio, Alessandra | Selvaraj, Saravanakumar | Inga, Alberto | Oh, Jung-Hwa | Spanel, Reinhard

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

2024 . Yu, Xin | Jiang, Juan | Li, Cheng | Wang, Yang | Ren, Zhengrong | Hu, Jianlun | Yuan, Tao | Wu, Yongjie | Wang, Dongsheng | Sun, Ziying | Wu, Qi | Chen, Bin | Fang, Peng | Ding, Hao | Meng, Jia | Jiang, Hui | Zhao, Jianning | Bao, Nirong

Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis

LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis

2021 . Szepanowski, Fabian | Winkelhausen, Maximilian | Steubing, Rebecca D. | Mausberg, Anne K. | Kleinschnitz, Christoph | Stettner, Mark

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

2020 . Millen, Sebastian | Meretuk, Lina | Göttlicher, Tim | Schmitt, Sarah | Fleckenstein, Bernhard | Thoma-Kress, Andrea K.